Discovering biomarkers associated with infiltration of CD8+ T cells and tumor-associated fibrosis in colon adenocarcinoma using single-cell RNA sequencing and gene co-expression network

Discovering biomarkers associated with infiltration of CD8+ T cells and tumor-associated fibrosis in colon adenocarcinoma using single-cell RNA sequencing and gene co-expression network

BackgroundColorectal adenocarcinoma (COAD) is a prevalent malignant tumor associated with a high mortality rate. Within the tumor microenvironment, CD8+ T cells play a pivotal role in the anti-tumor immune response within the human body. Fibrosis directly and indirectly affects the therapeutic respo...

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Bibliographic Details
Main Authors: Jinning Zhang, Ziquan Sun, Guodong Li, Lixian Ding, Zitong Wang, Ming Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
colon adenocarcinoma
CD8 + T cells
single-cell RNA sequencing
fibrosis
prognostic biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1496640/full
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