A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer
Abstract Background Everolimus is a mechanistic-target-of-rapamycin (mTOR) inhibitor bearing a potent antitumor effect against hormone receptor-positive breast cancer. Here, we report the case of a patient with recurrent breast cancer who developed osteomyelitis during the treatment with everolimus...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Surgical Society
2022-01-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40792-022-01376-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850056092846915584 |
|---|---|
| author | Kaori Abe Masafumi Shimoda Tetsuhiro Yoshinami Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Naofumi Kagara Yasuto Naoi Kenzo Shimazu |
| author_facet | Kaori Abe Masafumi Shimoda Tetsuhiro Yoshinami Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Naofumi Kagara Yasuto Naoi Kenzo Shimazu |
| author_sort | Kaori Abe |
| collection | DOAJ |
| description | Abstract Background Everolimus is a mechanistic-target-of-rapamycin (mTOR) inhibitor bearing a potent antitumor effect against hormone receptor-positive breast cancer. Here, we report the case of a patient with recurrent breast cancer who developed osteomyelitis during the treatment with everolimus plus exemestane. Case presentation A 56-year-old woman with early-stage breast cancer underwent right mastectomy and axillary lymph node dissection at the age of 45. Four years after the surgery, she experienced relapse at the chest wall. Radiotherapy was performed on the chest wall, including the sternum, and denosumab was administered. After several regimens of hormonal therapies, everolimus in combination with exemestane was administered. Three months later, the patient visited our clinic because of continuous fever. A computed tomography scan showed an osteolytic change in the sternal bone with pneumomediastinum, which indicated sternal osteomyelitis. Extensive debridement followed by secondary reconstruction of the chest wall was successfully performed. Conclusions Everolimus may cause osteomyelitis of the affected bone as a result of tumor necrosis. Everolimus-induced osteomyelitis may be manageable by extensive debridement performed without delay. |
| format | Article |
| id | doaj-art-eba388cc49fd4a3d90db9f002a36da61 |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-eba388cc49fd4a3d90db9f002a36da612025-08-20T02:51:46ZengJapan Surgical SocietySurgical Case Reports2198-77932022-01-01811410.1186/s40792-022-01376-yA case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancerKaori Abe0Masafumi Shimoda1Tetsuhiro Yoshinami2Yoshiaki Sota3Tomohiro Miyake4Tomonori Tanei5Naofumi Kagara6Yasuto Naoi7Kenzo Shimazu8Department of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineDepartment of Breast and Endocrine Surgery, Osaka University Graduate School of MedicineAbstract Background Everolimus is a mechanistic-target-of-rapamycin (mTOR) inhibitor bearing a potent antitumor effect against hormone receptor-positive breast cancer. Here, we report the case of a patient with recurrent breast cancer who developed osteomyelitis during the treatment with everolimus plus exemestane. Case presentation A 56-year-old woman with early-stage breast cancer underwent right mastectomy and axillary lymph node dissection at the age of 45. Four years after the surgery, she experienced relapse at the chest wall. Radiotherapy was performed on the chest wall, including the sternum, and denosumab was administered. After several regimens of hormonal therapies, everolimus in combination with exemestane was administered. Three months later, the patient visited our clinic because of continuous fever. A computed tomography scan showed an osteolytic change in the sternal bone with pneumomediastinum, which indicated sternal osteomyelitis. Extensive debridement followed by secondary reconstruction of the chest wall was successfully performed. Conclusions Everolimus may cause osteomyelitis of the affected bone as a result of tumor necrosis. Everolimus-induced osteomyelitis may be manageable by extensive debridement performed without delay.https://doi.org/10.1186/s40792-022-01376-ySternal osteomyelitisEverolimusmTOR inhibitorBreast cancerDenosumab |
| spellingShingle | Kaori Abe Masafumi Shimoda Tetsuhiro Yoshinami Yoshiaki Sota Tomohiro Miyake Tomonori Tanei Naofumi Kagara Yasuto Naoi Kenzo Shimazu A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer Surgical Case Reports Sternal osteomyelitis Everolimus mTOR inhibitor Breast cancer Denosumab |
| title | A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer |
| title_full | A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer |
| title_fullStr | A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer |
| title_full_unstemmed | A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer |
| title_short | A case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer |
| title_sort | case of sternal osteomyelitis during treatment with everolimus for recurrent breast cancer |
| topic | Sternal osteomyelitis Everolimus mTOR inhibitor Breast cancer Denosumab |
| url | https://doi.org/10.1186/s40792-022-01376-y |
| work_keys_str_mv | AT kaoriabe acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT masafumishimoda acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT tetsuhiroyoshinami acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT yoshiakisota acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT tomohiromiyake acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT tomonoritanei acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT naofumikagara acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT yasutonaoi acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT kenzoshimazu acaseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT kaoriabe caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT masafumishimoda caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT tetsuhiroyoshinami caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT yoshiakisota caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT tomohiromiyake caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT tomonoritanei caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT naofumikagara caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT yasutonaoi caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer AT kenzoshimazu caseofsternalosteomyelitisduringtreatmentwitheverolimusforrecurrentbreastcancer |