The impact of creatine supplementation on renal function: A case report and literature review
Creatine supplementation is one of the most widely used dietary supplements worldwide, yet its potential adverse effects on kidney function remain a concern. We report a case of a 25-year-old man who presented with symptoms of left renal colic and exhibited a temporary elevation in serum creatinine...
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International Network for the Advancement of Medicine, Psychology, and Public Health (INAMPPH)
2025-04-01
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| Series: | Advances in Medicine, Psychology, and Public Health |
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| Online Access: | https://ampphealthjournal-network.org/wp-content/uploads/2024/08/AMPPH_2025_131_135.pdf |
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| author | Antonio Villa Lucia Trotta Giovanni Faraci |
| author_facet | Antonio Villa Lucia Trotta Giovanni Faraci |
| author_sort | Antonio Villa |
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| description | Creatine supplementation is one of the most widely used dietary supplements worldwide, yet its potential adverse effects on kidney function remain a concern. We report a case of a 25-year-old man who presented with symptoms of left renal colic and exhibited a temporary elevation in serum creatinine levels following oral intake of 10 grams of creatine. Laboratory tests showed elevated serum creatinine (2.12 mg/dL) and urea (45 mg/dL), with an estimated creatinine clearance of 60.3 ml/min. After analgesic and antispastic treatment, the patient's symptoms resolved, and subsequent follow-up indicated normalization of renal function
parameters. While several longitudinal, controlled studies on the adverse effects of exogenous creatine supplementation have been published, no evidence of kidney function deterioration
has been observed in healthy subjects. Creatine supplementation can alter serum creatinine levels, potentially serving as a false indicator of kidney injury. In this case, we believe the observed increase in creatinine levels was a transient effect of exogenous creatine intake without any actual impairment of renal function.
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| format | Article |
| id | doaj-art-eba06ec4250944028be2a8946a2b0917 |
| institution | Kabale University |
| issn | 3034-8803 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | International Network for the Advancement of Medicine, Psychology, and Public Health (INAMPPH) |
| record_format | Article |
| series | Advances in Medicine, Psychology, and Public Health |
| spelling | doaj-art-eba06ec4250944028be2a8946a2b09172024-12-20T23:14:40ZengInternational Network for the Advancement of Medicine, Psychology, and Public Health (INAMPPH)Advances in Medicine, Psychology, and Public Health3034-88032025-04-012213113510.5281/zenodo.13239893The impact of creatine supplementation on renal function: A case report and literature reviewAntonio Villa0https://orcid.org/0009-0004-1634-6978Lucia Trotta1https://orcid.org/0000-0002-4130-5519Giovanni Faraci2https://orcid.org/0009-0007-3725-4580Fatebenefratelli Hospital, Milan; Internal Medicine Department, ItalyFatebenefratelli Hospital, Milan; Internal Medicine Department, ItalyFatebenefratelli Hospital, Milan; Internal Medicine Department, ItalyCreatine supplementation is one of the most widely used dietary supplements worldwide, yet its potential adverse effects on kidney function remain a concern. We report a case of a 25-year-old man who presented with symptoms of left renal colic and exhibited a temporary elevation in serum creatinine levels following oral intake of 10 grams of creatine. Laboratory tests showed elevated serum creatinine (2.12 mg/dL) and urea (45 mg/dL), with an estimated creatinine clearance of 60.3 ml/min. After analgesic and antispastic treatment, the patient's symptoms resolved, and subsequent follow-up indicated normalization of renal function parameters. While several longitudinal, controlled studies on the adverse effects of exogenous creatine supplementation have been published, no evidence of kidney function deterioration has been observed in healthy subjects. Creatine supplementation can alter serum creatinine levels, potentially serving as a false indicator of kidney injury. In this case, we believe the observed increase in creatinine levels was a transient effect of exogenous creatine intake without any actual impairment of renal function. https://ampphealthjournal-network.org/wp-content/uploads/2024/08/AMPPH_2025_131_135.pdfadverse effectscreatinedietary supplementskidney diseaserenal function |
| spellingShingle | Antonio Villa Lucia Trotta Giovanni Faraci The impact of creatine supplementation on renal function: A case report and literature review Advances in Medicine, Psychology, and Public Health adverse effects creatine dietary supplements kidney disease renal function |
| title | The impact of creatine supplementation on renal function: A case report and literature review |
| title_full | The impact of creatine supplementation on renal function: A case report and literature review |
| title_fullStr | The impact of creatine supplementation on renal function: A case report and literature review |
| title_full_unstemmed | The impact of creatine supplementation on renal function: A case report and literature review |
| title_short | The impact of creatine supplementation on renal function: A case report and literature review |
| title_sort | impact of creatine supplementation on renal function a case report and literature review |
| topic | adverse effects creatine dietary supplements kidney disease renal function |
| url | https://ampphealthjournal-network.org/wp-content/uploads/2024/08/AMPPH_2025_131_135.pdf |
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