5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis

A randomized clinical trial of the efficacy and safety of two different dosages of 5-aminosalicylic acid (5-ASA) enemas was carried out in 29 patients who had documented ulcerative colitis involving up to 50cm of distal colon. All patients were in remission or had minimal disease activity (Disease A...

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Main Authors: Lloyd R Sutherland, Francois Martin
Format: Article
Language:English
Published: Wiley 1987-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1987/846392
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author Lloyd R Sutherland
Francois Martin
author_facet Lloyd R Sutherland
Francois Martin
author_sort Lloyd R Sutherland
collection DOAJ
description A randomized clinical trial of the efficacy and safety of two different dosages of 5-aminosalicylic acid (5-ASA) enemas was carried out in 29 patients who had documented ulcerative colitis involving up to 50cm of distal colon. All patients were in remission or had minimal disease activity (Disease Activity Index [DAI] less than 4) at the time of study entry. The two patient groups were similar in terms of age, sex ratio and disease activity. Further significant reduction in DAI occurred during the first three months of the study. Five patients (two in the 2 g group and three in the 4g group) relapsed over the next six months. There were no significant differences in DAI of the two groups over the six month study period (ANOVA for repeated measures). Six patients dropped out of the study all of whom were in remission when last seen (mean follow-up 3. 3 months). In this preliminary study, 2 g enemas were shown to be as effective as 4 g enemas in maintaining remission in patients with ulcerative colitis confined to the distal colon.
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spelling doaj-art-eba01a44fb0745899feb733745c092c22025-02-03T05:58:48ZengWileyCanadian Journal of Gastroenterology0835-79001987-01-01113610.1155/1987/8463925-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and ProctitisLloyd R SutherlandFrancois MartinA randomized clinical trial of the efficacy and safety of two different dosages of 5-aminosalicylic acid (5-ASA) enemas was carried out in 29 patients who had documented ulcerative colitis involving up to 50cm of distal colon. All patients were in remission or had minimal disease activity (Disease Activity Index [DAI] less than 4) at the time of study entry. The two patient groups were similar in terms of age, sex ratio and disease activity. Further significant reduction in DAI occurred during the first three months of the study. Five patients (two in the 2 g group and three in the 4g group) relapsed over the next six months. There were no significant differences in DAI of the two groups over the six month study period (ANOVA for repeated measures). Six patients dropped out of the study all of whom were in remission when last seen (mean follow-up 3. 3 months). In this preliminary study, 2 g enemas were shown to be as effective as 4 g enemas in maintaining remission in patients with ulcerative colitis confined to the distal colon.http://dx.doi.org/10.1155/1987/846392
spellingShingle Lloyd R Sutherland
Francois Martin
5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
Canadian Journal of Gastroenterology
title 5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
title_full 5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
title_fullStr 5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
title_full_unstemmed 5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
title_short 5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
title_sort 5 aminosalicylic acid enemas in the maintenance of remission in distal ulcerative colitis and proctitis
url http://dx.doi.org/10.1155/1987/846392
work_keys_str_mv AT lloydrsutherland 5aminosalicylicacidenemasinthemaintenanceofremissionindistalulcerativecolitisandproctitis
AT francoismartin 5aminosalicylicacidenemasinthemaintenanceofremissionindistalulcerativecolitisandproctitis