5-Aminosalicylic Acid Enemas in the Maintenance of Remission in Distal Ulcerative Colitis and Proctitis
A randomized clinical trial of the efficacy and safety of two different dosages of 5-aminosalicylic acid (5-ASA) enemas was carried out in 29 patients who had documented ulcerative colitis involving up to 50cm of distal colon. All patients were in remission or had minimal disease activity (Disease A...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1987-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1987/846392 |
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| Summary: | A randomized clinical trial of the efficacy and safety of two different
dosages of 5-aminosalicylic acid (5-ASA) enemas was carried out in 29 patients who
had documented ulcerative colitis involving up to 50cm of distal colon. All patients
were in remission or had minimal disease activity (Disease Activity Index [DAI] less
than 4) at the time of study entry. The two patient groups were similar in terms of age,
sex ratio and disease activity. Further significant reduction in DAI occurred during
the first three months of the study. Five patients (two in the 2 g group and three in the
4g group) relapsed over the next six months. There were no significant differences in
DAI of the two groups over the six month study period (ANOVA for repeated
measures). Six patients dropped out of the study all of whom were in remission when
last seen (mean follow-up 3. 3 months). In this preliminary study, 2 g enemas were
shown to be as effective as 4 g enemas in maintaining remission in patients with
ulcerative colitis confined to the distal colon. |
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| ISSN: | 0835-7900 |