CTCF, Cohesin, and Chromatin in Human Cancer
It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spati...
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| Format: | Article |
| Language: | English |
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BioMed Central
2017-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2017-15-4-114.pdf |
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| _version_ | 1832572846478458880 |
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| author | Sang-Hyun Song Tae-You Kim |
| author_facet | Sang-Hyun Song Tae-You Kim |
| author_sort | Sang-Hyun Song |
| collection | DOAJ |
| description | It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression. |
| format | Article |
| id | doaj-art-eb9d2925bc1f458996df99cba53dacc8 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-eb9d2925bc1f458996df99cba53dacc82025-02-02T06:54:52ZengBioMed CentralGenomics & Informatics2234-07422017-12-0115411412210.5808/GI.2017.15.4.114493CTCF, Cohesin, and Chromatin in Human CancerSang-Hyun Song0Tae-You Kim1 Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University, Seoul 03080, Korea Cancer Genomics Research Laboratory, Cancer Research Institute, Seoul National University, Seoul 03080, KoreaIt is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.http://genominfo.org/upload/pdf/gi-2017-15-4-114.pdfcohesinsCTCFgene expression regulationhigher-order chromatin structuretopologically associated domain |
| spellingShingle | Sang-Hyun Song Tae-You Kim CTCF, Cohesin, and Chromatin in Human Cancer Genomics & Informatics cohesins CTCF gene expression regulation higher-order chromatin structure topologically associated domain |
| title | CTCF, Cohesin, and Chromatin in Human Cancer |
| title_full | CTCF, Cohesin, and Chromatin in Human Cancer |
| title_fullStr | CTCF, Cohesin, and Chromatin in Human Cancer |
| title_full_unstemmed | CTCF, Cohesin, and Chromatin in Human Cancer |
| title_short | CTCF, Cohesin, and Chromatin in Human Cancer |
| title_sort | ctcf cohesin and chromatin in human cancer |
| topic | cohesins CTCF gene expression regulation higher-order chromatin structure topologically associated domain |
| url | http://genominfo.org/upload/pdf/gi-2017-15-4-114.pdf |
| work_keys_str_mv | AT sanghyunsong ctcfcohesinandchromatininhumancancer AT taeyoukim ctcfcohesinandchromatininhumancancer |