Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt
Abstract During aging, arterial stiffness and blood pressure (BP) increase, while heart rate variability (HRV) decreases. We examined age‐related hemodynamics in 522 individuals without cardiovascular disease during passive head‐up tilt (HUT) using pulse wave analysis, whole‐body impedance cardiogra...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70477 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849730405072109568 |
|---|---|
| author | Manoj Kumar Choudhary Kati Holmström Heidi Bouquin Tuomas P. Saarinen Jenni K. Koskela Essi Pietilä Lauri Suojanen Jukka T. Mustonen Pasi I. Nevalainen Ilkka H. Pörsti |
| author_facet | Manoj Kumar Choudhary Kati Holmström Heidi Bouquin Tuomas P. Saarinen Jenni K. Koskela Essi Pietilä Lauri Suojanen Jukka T. Mustonen Pasi I. Nevalainen Ilkka H. Pörsti |
| author_sort | Manoj Kumar Choudhary |
| collection | DOAJ |
| description | Abstract During aging, arterial stiffness and blood pressure (BP) increase, while heart rate variability (HRV) decreases. We examined age‐related hemodynamics in 522 individuals without cardiovascular disease during passive head‐up tilt (HUT) using pulse wave analysis, whole‐body impedance cardiography, and HRV analysis. Mean age was 44 years, body mass index 26 kg/m2, and office BP 138/88 mmHg. Cardiac output was 7% higher in the youngest quartile than the oldest. With increasing age, aortic BP, pulse pressure, pulse wave velocity, wave reflection, and systemic vascular resistance increased, while heart rate, pulse pressure amplification, and aortic reflection time decreased. During HUT, aging was linked to greater reductions in systolic BP, pulse pressure, and stroke volume, as well as diminished heart rate increase and reduced aortic reflection time shortening. HRV in low‐frequency (LF) and high‐frequency (HF) power decreased with age. However, the supine LF:HF ratio was higher in the oldest quartile than the youngest, a pattern not seen during HUT. In conclusion, higher arterial stiffness and systemic vascular resistance likely contribute to age‐related rises in BP and pulse pressure, reduced pulse pressure amplification, and shorter aortic reflection time. Although HRV decreased with age, the supine LF:HF ratio increased, a change absent in the upright position. |
| format | Article |
| id | doaj-art-eb9c64b897214d78839cdf5019fefdfa |
| institution | DOAJ |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-eb9c64b897214d78839cdf5019fefdfa2025-08-20T03:08:52ZengWileyPhysiological Reports2051-817X2025-07-011314n/an/a10.14814/phy2.70477Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tiltManoj Kumar Choudhary0Kati Holmström1Heidi Bouquin2Tuomas P. Saarinen3Jenni K. Koskela4Essi Pietilä5Lauri Suojanen6Jukka T. Mustonen7Pasi I. Nevalainen8Ilkka H. Pörsti9Faculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandDepartment of Internal Medicine Tampere University Hospital Tampere FinlandFaculty of Medicine and Health Technology Tampere University Tampere FinlandAbstract During aging, arterial stiffness and blood pressure (BP) increase, while heart rate variability (HRV) decreases. We examined age‐related hemodynamics in 522 individuals without cardiovascular disease during passive head‐up tilt (HUT) using pulse wave analysis, whole‐body impedance cardiography, and HRV analysis. Mean age was 44 years, body mass index 26 kg/m2, and office BP 138/88 mmHg. Cardiac output was 7% higher in the youngest quartile than the oldest. With increasing age, aortic BP, pulse pressure, pulse wave velocity, wave reflection, and systemic vascular resistance increased, while heart rate, pulse pressure amplification, and aortic reflection time decreased. During HUT, aging was linked to greater reductions in systolic BP, pulse pressure, and stroke volume, as well as diminished heart rate increase and reduced aortic reflection time shortening. HRV in low‐frequency (LF) and high‐frequency (HF) power decreased with age. However, the supine LF:HF ratio was higher in the oldest quartile than the youngest, a pattern not seen during HUT. In conclusion, higher arterial stiffness and systemic vascular resistance likely contribute to age‐related rises in BP and pulse pressure, reduced pulse pressure amplification, and shorter aortic reflection time. Although HRV decreased with age, the supine LF:HF ratio increased, a change absent in the upright position.https://doi.org/10.14814/phy2.70477agingblood pressurehead‐up tiltheart ratehemodynamics |
| spellingShingle | Manoj Kumar Choudhary Kati Holmström Heidi Bouquin Tuomas P. Saarinen Jenni K. Koskela Essi Pietilä Lauri Suojanen Jukka T. Mustonen Pasi I. Nevalainen Ilkka H. Pörsti Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt Physiological Reports aging blood pressure head‐up tilt heart rate hemodynamics |
| title | Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt |
| title_full | Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt |
| title_fullStr | Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt |
| title_full_unstemmed | Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt |
| title_short | Impact of aging on cardiovascular dynamics and heart rate variability during passive head‐up tilt |
| title_sort | impact of aging on cardiovascular dynamics and heart rate variability during passive head up tilt |
| topic | aging blood pressure head‐up tilt heart rate hemodynamics |
| url | https://doi.org/10.14814/phy2.70477 |
| work_keys_str_mv | AT manojkumarchoudhary impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT katiholmstrom impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT heidibouquin impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT tuomaspsaarinen impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT jennikkoskela impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT essipietila impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT laurisuojanen impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT jukkatmustonen impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT pasiinevalainen impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt AT ilkkahporsti impactofagingoncardiovasculardynamicsandheartratevariabilityduringpassiveheaduptilt |