Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA

Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA

Hepatitis B virus (HBV) can cause chronic infections, significantly increasing the risk of death from cirrhosis and hepatocellular carcinoma (HCC). A key player in chronic HBV infection is covalently closed circular DNA (cccDNA), a stable episomal form of viral DNA that acts as a persistent reservoi...

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Bibliographic Details
Main Authors: Deok-Hwa Seo, Wonhee Hur, Juhee Won, Ji-Won Han, Seung-Kew Yoon, Songmee Bae, Kyun-Hwan Kim, Pil-Soo Sung
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
Hepatitis B virus
genotype C
cccDNA
mouse model
chronic HBV infection
Online Access:https://www.mdpi.com/1999-4915/16/12/1890
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