Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways

Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways

IntroductionRight ventricular failure is a life-threatening condition commonly associated with obvious immune responses in its progression. This study aims to investigate the role of osteopontin (OPN) in right ventricular failure pathogenesis and evaluate its potential as a therapeutic target.Method...

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Bibliographic Details
Main Authors: Xiaomei Yang, Xuyang Wang, Kai Li, Qiming Deng, Yonghao Hou, Guangmin Xi, Kangping Lu, Zihua Liu, Yu Bai, Jianbo Wu, Jingui Yu, Peng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
right ventricular failure
osteopontin
endoplasmic reticulum stress
apoptosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569210/full
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