Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis

Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis

Abstract Background Pulmonary fibrosis, a major complication of severe COVID-19 and post-acute sequelae of SARS-CoV-2 infection (PASC), is driven by excessive neutrophil activation and the formation of neutrophil extracellular trap (NET). Results This study presents a sequential nanoparticle-based t...

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Bibliographic Details
Main Authors: Hye-Jin Lee, Na Kyeong Lee, Jisun Kim, Jungbum Kim, Donghyuk Seo, Ha Eun Shin, Jongsu Kim, June Hong Ahn, Se-Na Kim, Hong Sook Kim, Juwon Park, Wooram Park, Kyung Soo Hong, Chun Gwon Park, Wonhwa Lee
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Pulmonary fibrosis
Neutrophil extracellular traps
Aerosolized drug delivery
Chronic inflammation
Post-acute sequelae of SARS-CoV-2 (PASC)
Online Access:https://doi.org/10.1186/s12951-025-03421-y
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