Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study
ABSTRACT The association between circulating fatty acids (FAs) and mortality remains unclear. This study investigates the association between circulating FA and mortality, focusing on all‐cause and cardiovascular disease (CVD) mortality. Using data from 2517 individuals (mean age 48.2 years) in the...
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Wiley
2025-06-01
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| Online Access: | https://doi.org/10.1002/efd2.70062 |
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| author | Xiaogang Lv Qianqian Ji Qi Liu Qingya Zhao Yue Xu Yaxian Meng Liqiong Zhou Zhao Hu Na Wang Yiqiang Zhan |
| author_facet | Xiaogang Lv Qianqian Ji Qi Liu Qingya Zhao Yue Xu Yaxian Meng Liqiong Zhou Zhao Hu Na Wang Yiqiang Zhan |
| author_sort | Xiaogang Lv |
| collection | DOAJ |
| description | ABSTRACT The association between circulating fatty acids (FAs) and mortality remains unclear. This study investigates the association between circulating FA and mortality, focusing on all‐cause and cardiovascular disease (CVD) mortality. Using data from 2517 individuals (mean age 48.2 years) in the National Health and Nutrition Examination Survey (2011–2014), we analyzed FA levels and mortality using a weighted Cox proportional hazards model, with sex‐stratified analysis. In addition, restricted cubic spline was used to evaluate the FAs and all‐cause mortality on a continuous scale. Over 16,660 person‐years, 213 deaths occurred, including 73 from CVD. After multivariable adjustment, circulating saturated fatty acids (SFAs; arachidic, docosanoic, tricosanoic, and lignoceric acids) were associated with lower all‐cause mortality risk (HR per 1‐SD [95% CI]: 0.76 [0.59–0.97], 0.69 [0.56–0.85], 0.63 [0.52–0.77], 0.68 [0.59–0.80], respectively). In contrast, monounsaturated fatty acids (MUFAs; myristoleic, palmitoleic, and cis−Vaccenic acids) were associated with higher all‐cause mortality risk (HR per 1‐SD [95% CI]: 1.13 [1.04–1.23], 1.18 [1.09–1.27], 1.20 [1.09–1.32], respectively). Similar trends were observed for CVD mortality. l‐shaped nonlinear associations indicated that the lowest risk of all‐cause mortality occurred at FA concentrations between 25 and 65 μmol/L. These findings highlight the complex relationship between FAs and mortality in US adults. |
| format | Article |
| id | doaj-art-eb9109ca497343b8a95562bb78cc2103 |
| institution | Kabale University |
| issn | 2666-3066 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | eFood |
| spelling | doaj-art-eb9109ca497343b8a95562bb78cc21032025-08-20T03:44:39ZengWileyeFood2666-30662025-06-0163n/an/a10.1002/efd2.70062Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort StudyXiaogang Lv0Qianqian Ji1Qi Liu2Qingya Zhao3Yue Xu4Yaxian Meng5Liqiong Zhou6Zhao Hu7Na Wang8Yiqiang Zhan9Department of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaDepartment of Epidemiology, School of Public Health Guilin Medical University Guilin ChinaDepartment of Epidemiology, School of Public Health (Shenzhen) Sun Yat‐sen University Shenzhen ChinaABSTRACT The association between circulating fatty acids (FAs) and mortality remains unclear. This study investigates the association between circulating FA and mortality, focusing on all‐cause and cardiovascular disease (CVD) mortality. Using data from 2517 individuals (mean age 48.2 years) in the National Health and Nutrition Examination Survey (2011–2014), we analyzed FA levels and mortality using a weighted Cox proportional hazards model, with sex‐stratified analysis. In addition, restricted cubic spline was used to evaluate the FAs and all‐cause mortality on a continuous scale. Over 16,660 person‐years, 213 deaths occurred, including 73 from CVD. After multivariable adjustment, circulating saturated fatty acids (SFAs; arachidic, docosanoic, tricosanoic, and lignoceric acids) were associated with lower all‐cause mortality risk (HR per 1‐SD [95% CI]: 0.76 [0.59–0.97], 0.69 [0.56–0.85], 0.63 [0.52–0.77], 0.68 [0.59–0.80], respectively). In contrast, monounsaturated fatty acids (MUFAs; myristoleic, palmitoleic, and cis−Vaccenic acids) were associated with higher all‐cause mortality risk (HR per 1‐SD [95% CI]: 1.13 [1.04–1.23], 1.18 [1.09–1.27], 1.20 [1.09–1.32], respectively). Similar trends were observed for CVD mortality. l‐shaped nonlinear associations indicated that the lowest risk of all‐cause mortality occurred at FA concentrations between 25 and 65 μmol/L. These findings highlight the complex relationship between FAs and mortality in US adults.https://doi.org/10.1002/efd2.70062cardiovascular diseasescohort studiesfatty acidsmortalityNHANES |
| spellingShingle | Xiaogang Lv Qianqian Ji Qi Liu Qingya Zhao Yue Xu Yaxian Meng Liqiong Zhou Zhao Hu Na Wang Yiqiang Zhan Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study eFood cardiovascular diseases cohort studies fatty acids mortality NHANES |
| title | Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study |
| title_full | Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study |
| title_fullStr | Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study |
| title_full_unstemmed | Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study |
| title_short | Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study |
| title_sort | association of circulating fatty acid profiles with cardiovascular and all cause mortality in the general population a cohort study |
| topic | cardiovascular diseases cohort studies fatty acids mortality NHANES |
| url | https://doi.org/10.1002/efd2.70062 |
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