SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS
A simple prospective investigation studied the efficacy of reamberine used to prevent antituberculosis drug-induced hepatitis in 144 patients with new-onset infiltrative pulmonary tuberculosis who were divided into 2 groups: 1) those who received a 1-2-week reamberine cycle (a study group) and 2) th...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2014-06-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/93 |
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| author | A. V. Mordykh O. G. Ivanova L. A. Nagibina S. V. Sitnikov |
| author_facet | A. V. Mordykh O. G. Ivanova L. A. Nagibina S. V. Sitnikov |
| author_sort | A. V. Mordykh |
| collection | DOAJ |
| description | A simple prospective investigation studied the efficacy of reamberine used to prevent antituberculosis drug-induced hepatitis in 144 patients with new-onset infiltrative pulmonary tuberculosis who were divided into 2 groups: 1) those who received a 1-2-week reamberine cycle (a study group) and 2) those who did not (a comparison group). In the study group, arrest of the symptoms of intoxication (by the leukocyte index by 35.3%) occurred in a shorter periods; drug-induced hepatitides, whose course was more favorable, were noted to develop less commonly (16.6 versus 36%). In the study group, therapeutic effectiveness was higher than that in the comparison group in terms of both the decay cavity closure index (by 30.2%) and the bacterial cessation index (by 24.8%), including in patients with multidrug-resistant in the pathogen, decay cavities were closed 13.9% more frequently and bacterial excretion cessation was seen 27.8% more often; transformation to fibrocavernous tuberculosis was also observed less commonly. The findings allow one to recommend the use of reamberine as an agent for the prevention of hepatitis caused by the intake of antituberculosis drugs during patients’ adaptation to chemotherapy (1-2weeks of treatment). |
| format | Article |
| id | doaj-art-eb8e85dc4b7e427697de4d296c5237ab |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2014-06-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-eb8e85dc4b7e427697de4d296c5237ab2025-08-20T02:15:53ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062014-06-0106616510.21292/2075-1230-2014-0-6-61-6593SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSISA. V. Mordykh0O. G. Ivanova1L. A. Nagibina2S. V. Sitnikov3ГБОУ ВПО «Омская государственная медицинская академия» Минздрава РоссииГБОУ ВПО «Омская государственная медицинская академия» Минздрава РоссииКУЗОО «Клинический противотуберкулезный диспансер № 4»КУЗОО «Клинический противотуберкулезный диспансер № 4»A simple prospective investigation studied the efficacy of reamberine used to prevent antituberculosis drug-induced hepatitis in 144 patients with new-onset infiltrative pulmonary tuberculosis who were divided into 2 groups: 1) those who received a 1-2-week reamberine cycle (a study group) and 2) those who did not (a comparison group). In the study group, arrest of the symptoms of intoxication (by the leukocyte index by 35.3%) occurred in a shorter periods; drug-induced hepatitides, whose course was more favorable, were noted to develop less commonly (16.6 versus 36%). In the study group, therapeutic effectiveness was higher than that in the comparison group in terms of both the decay cavity closure index (by 30.2%) and the bacterial cessation index (by 24.8%), including in patients with multidrug-resistant in the pathogen, decay cavities were closed 13.9% more frequently and bacterial excretion cessation was seen 27.8% more often; transformation to fibrocavernous tuberculosis was also observed less commonly. The findings allow one to recommend the use of reamberine as an agent for the prevention of hepatitis caused by the intake of antituberculosis drugs during patients’ adaptation to chemotherapy (1-2weeks of treatment).https://www.tibl-journal.com/jour/article/view/93infiltrative tuberculosisadverse reactionsdrug-induced liver injuryreamberine |
| spellingShingle | A. V. Mordykh O. G. Ivanova L. A. Nagibina S. V. Sitnikov SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS Туберкулез и болезни лёгких infiltrative tuberculosis adverse reactions drug-induced liver injury reamberine |
| title | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_full | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_fullStr | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_full_unstemmed | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_short | SUCCINIC ACID PREPARATIONS IN THE COMBINATION TREATMENT OF PATIENTS WITH TUBERCULOSIS |
| title_sort | succinic acid preparations in the combination treatment of patients with tuberculosis |
| topic | infiltrative tuberculosis adverse reactions drug-induced liver injury reamberine |
| url | https://www.tibl-journal.com/jour/article/view/93 |
| work_keys_str_mv | AT avmordykh succinicacidpreparationsinthecombinationtreatmentofpatientswithtuberculosis AT ogivanova succinicacidpreparationsinthecombinationtreatmentofpatientswithtuberculosis AT lanagibina succinicacidpreparationsinthecombinationtreatmentofpatientswithtuberculosis AT svsitnikov succinicacidpreparationsinthecombinationtreatmentofpatientswithtuberculosis |