Tracing immature myelin in acute disseminated encephalomyelitis

Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immat...

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Main Authors: Banu Anlar, Kader Karli-Oğuz, Osman Yücel Yurtyapan, Nesrin Senbil, Ozlem Hergüner, Sakir Altunbaşak, F Müjgan Sönmez, Pinar Ozdemir-Geyik
Format: Article
Language:English
Published: Hacettepe University Institute of Child Health 2006-07-01
Series:The Turkish Journal of Pediatrics
Online Access:https://turkjpediatr.org/article/view/2629
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author Banu Anlar
Kader Karli-Oğuz
Osman Yücel Yurtyapan
Nesrin Senbil
Ozlem Hergüner
Sakir Altunbaşak
F Müjgan Sönmez
Pinar Ozdemir-Geyik
author_facet Banu Anlar
Kader Karli-Oğuz
Osman Yücel Yurtyapan
Nesrin Senbil
Ozlem Hergüner
Sakir Altunbaşak
F Müjgan Sönmez
Pinar Ozdemir-Geyik
author_sort Banu Anlar
collection DOAJ
description Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system.
format Article
id doaj-art-eb8a048180df43249a1d361e9fb7de87
institution DOAJ
issn 0041-4301
2791-6421
language English
publishDate 2006-07-01
publisher Hacettepe University Institute of Child Health
record_format Article
series The Turkish Journal of Pediatrics
spelling doaj-art-eb8a048180df43249a1d361e9fb7de872025-08-20T03:16:23ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212006-07-01483Tracing immature myelin in acute disseminated encephalomyelitisBanu Anlar0Kader Karli-OğuzOsman Yücel YurtyapanNesrin SenbilOzlem HergünerSakir AltunbaşakF Müjgan SönmezPinar Ozdemir-GeyikDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system. https://turkjpediatr.org/article/view/2629
spellingShingle Banu Anlar
Kader Karli-Oğuz
Osman Yücel Yurtyapan
Nesrin Senbil
Ozlem Hergüner
Sakir Altunbaşak
F Müjgan Sönmez
Pinar Ozdemir-Geyik
Tracing immature myelin in acute disseminated encephalomyelitis
The Turkish Journal of Pediatrics
title Tracing immature myelin in acute disseminated encephalomyelitis
title_full Tracing immature myelin in acute disseminated encephalomyelitis
title_fullStr Tracing immature myelin in acute disseminated encephalomyelitis
title_full_unstemmed Tracing immature myelin in acute disseminated encephalomyelitis
title_short Tracing immature myelin in acute disseminated encephalomyelitis
title_sort tracing immature myelin in acute disseminated encephalomyelitis
url https://turkjpediatr.org/article/view/2629
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AT nesrinsenbil tracingimmaturemyelininacutedisseminatedencephalomyelitis
AT ozlemherguner tracingimmaturemyelininacutedisseminatedencephalomyelitis
AT sakiraltunbasak tracingimmaturemyelininacutedisseminatedencephalomyelitis
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