Decoding TGR5: A comprehensive review of its impact on cerebral diseases
Currently, unraveling the enigmatic realm of drug targets for cerebral disorders poses a formidable challenge. Takeda G protein-coupled receptor 5 (TGR5), also known as G protein-coupled bile acid receptor 1, is a specific bile acid receptor. Widely distributed across various tissues, TGR5 orchestra...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000969 |
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| author | Zehan Zhang Yifei Zhang Hongye Peng Qingqian Yu Xiangdong Kang Ying Liu Yuxiao Zheng Fafeng Cheng Xueqian Wang Feng Li |
| author_facet | Zehan Zhang Yifei Zhang Hongye Peng Qingqian Yu Xiangdong Kang Ying Liu Yuxiao Zheng Fafeng Cheng Xueqian Wang Feng Li |
| author_sort | Zehan Zhang |
| collection | DOAJ |
| description | Currently, unraveling the enigmatic realm of drug targets for cerebral disorders poses a formidable challenge. Takeda G protein-coupled receptor 5 (TGR5), also known as G protein-coupled bile acid receptor 1, is a specific bile acid receptor. Widely distributed across various tissues, TGR5 orchestrates a myriad of biological functions encompassing inflammation, energy metabolism, fatty acid metabolism, immune responses, cellular proliferation, apoptosis, and beyond. Alongside its well-documented implications in liver diseases, obesity, type 2 diabetes, tumors, and cardiovascular diseases, a growing body of evidence accentuates the pivotal role of TGR5 in cerebral diseases. Thus, this comprehensive review aimed to scrutinize the current insights into the pathological mechanisms involving TGR5 in cerebral diseases, while contemplating its potential as a promising therapeutic target for cerebral diseases. |
| format | Article |
| id | doaj-art-eb890cebe93e4628868c01537e8c84bb |
| institution | DOAJ |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-eb890cebe93e4628868c01537e8c84bb2025-08-20T03:16:18ZengElsevierPharmacological Research1096-11862025-03-0121310767110.1016/j.phrs.2025.107671Decoding TGR5: A comprehensive review of its impact on cerebral diseasesZehan Zhang0Yifei Zhang1Hongye Peng2Qingqian Yu3Xiangdong Kang4Ying Liu5Yuxiao Zheng6Fafeng Cheng7Xueqian Wang8Feng Li9Beijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaBeijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaCorresponding authors.; Beijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaCorresponding authors.; Beijing University of Chinese Medicine, The northeast corner of the intersection of Sunshine South Street and Baiyang East Road, Beijing 102488, ChinaCurrently, unraveling the enigmatic realm of drug targets for cerebral disorders poses a formidable challenge. Takeda G protein-coupled receptor 5 (TGR5), also known as G protein-coupled bile acid receptor 1, is a specific bile acid receptor. Widely distributed across various tissues, TGR5 orchestrates a myriad of biological functions encompassing inflammation, energy metabolism, fatty acid metabolism, immune responses, cellular proliferation, apoptosis, and beyond. Alongside its well-documented implications in liver diseases, obesity, type 2 diabetes, tumors, and cardiovascular diseases, a growing body of evidence accentuates the pivotal role of TGR5 in cerebral diseases. Thus, this comprehensive review aimed to scrutinize the current insights into the pathological mechanisms involving TGR5 in cerebral diseases, while contemplating its potential as a promising therapeutic target for cerebral diseases.http://www.sciencedirect.com/science/article/pii/S1043661825000969TGR5Cerebral diseasesBiological processTherapeutic targetAgonist |
| spellingShingle | Zehan Zhang Yifei Zhang Hongye Peng Qingqian Yu Xiangdong Kang Ying Liu Yuxiao Zheng Fafeng Cheng Xueqian Wang Feng Li Decoding TGR5: A comprehensive review of its impact on cerebral diseases Pharmacological Research TGR5 Cerebral diseases Biological process Therapeutic target Agonist |
| title | Decoding TGR5: A comprehensive review of its impact on cerebral diseases |
| title_full | Decoding TGR5: A comprehensive review of its impact on cerebral diseases |
| title_fullStr | Decoding TGR5: A comprehensive review of its impact on cerebral diseases |
| title_full_unstemmed | Decoding TGR5: A comprehensive review of its impact on cerebral diseases |
| title_short | Decoding TGR5: A comprehensive review of its impact on cerebral diseases |
| title_sort | decoding tgr5 a comprehensive review of its impact on cerebral diseases |
| topic | TGR5 Cerebral diseases Biological process Therapeutic target Agonist |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000969 |
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