Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection

Integrated analyses of Mendelian randomization, eQTL, and single-cell transcriptome identify CCN3 as a potential biomarker in aortic dissection

Abstract Plasma secretory proteins are associated with various diseases, including aortic dissection (AD). However, current research on the correlation between AD and plasma protein levels is scarce or lacks specificity. This study aimed to explore plasma secretory proteins as potential biomarkers f...

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Main Authors: Haoyu Ran, Changying Li, Syed M. Musa Rizvi, Ruiqin Zhou, Lingwen Kong, Sun Shuangling, Yue Shao, Kejia Wu, Changzhu Duan, Jun Luo, Haoming Shi, Qingchen Wu, Cheng Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Aortic dissection
Plasma secretory proteins
CCN3
GWAS
eQTL
Online Access:https://doi.org/10.1038/s41598-024-83611-0
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