Protective effects of 4-HBd on blood–brain barrier integrity in MCAO/R model rats based on brain pharmacokinetic characteristics

Protective effects of 4-HBd on blood–brain barrier integrity in MCAO/R model rats based on brain pharmacokinetic characteristics

ObjectivesThis study explored the brain-targeting properties and mechanisms of 4-hydroxybenzaldehyde (4-HBd), the primary active component of Gastrodia elata, in mitigating ischemic stroke (IS)-induced injury by preserving blood–brain barrier (BBB) integrity, based on brain pharmacokinetic character...

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Bibliographic Details
Main Authors: Jin Feng, Qian Yang, Ming Chen, Yan Wang, Dan Luo, Dongxiong Hu, Jianjun Cheng, Xuelan Song, Xiaonan Zhou, Qingting Meng, Qing Lin, Fangyan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
4-hydroxybenzaldehyde
blood–brain barrier
tight junction
brain pharmacokinetics
microdialysis
single-cell biochemical analyzer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1528839/full
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