Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity
Conclusions: These data implied that H-2-168 may initiate apoptosis in PC12 cells by influencing the balance between mitochondrial fusion and division, accompanied by changes in energy metabolism, which may induce neurotoxicity.
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/jimr/6678026 |
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| _version_ | 1849336603807318016 |
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| author | Yuehong Gong Meichi Pan Hang Ren Dongling Peng Meiling Zhao Yicong Zhao Chunlin Luo Qin Ma Hao Wen Jianhua Wang |
| author_facet | Yuehong Gong Meichi Pan Hang Ren Dongling Peng Meiling Zhao Yicong Zhao Chunlin Luo Qin Ma Hao Wen Jianhua Wang |
| author_sort | Yuehong Gong |
| collection | DOAJ |
| description | Conclusions: These data implied that H-2-168 may initiate apoptosis in PC12 cells by influencing the balance between mitochondrial fusion and division, accompanied by changes in energy metabolism, which may induce neurotoxicity. |
| format | Article |
| id | doaj-art-eb7db0ddb69a4dbc8d6bbb5183909d67 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-eb7db0ddb69a4dbc8d6bbb5183909d672025-08-20T03:44:55ZengWileyJournal of Immunology Research2314-71562025-01-01202510.1155/jimr/6678026Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced NeurotoxicityYuehong Gong0Meichi Pan1Hang Ren2Dongling Peng3Meiling Zhao4Yicong Zhao5Chunlin Luo6Qin Ma7Hao Wen8Jianhua Wang9Department of PharmacognosyDepartment of PharmacognosyDepartment of MedicineDepartment of PharmacognosyDepartment of PharmacognosyDepartment of PharmacognosyDepartment of PharmacognosyResearch and Development DepartmentState Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central AsiaDepartment of PharmacognosyConclusions: These data implied that H-2-168 may initiate apoptosis in PC12 cells by influencing the balance between mitochondrial fusion and division, accompanied by changes in energy metabolism, which may induce neurotoxicity.http://dx.doi.org/10.1155/jimr/6678026 |
| spellingShingle | Yuehong Gong Meichi Pan Hang Ren Dongling Peng Meiling Zhao Yicong Zhao Chunlin Luo Qin Ma Hao Wen Jianhua Wang Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity Journal of Immunology Research |
| title | Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity |
| title_full | Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity |
| title_fullStr | Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity |
| title_full_unstemmed | Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity |
| title_short | Roles of Mitochondrial Fusion and Division in Harmine Derivative H-2-168-Induced Neurotoxicity |
| title_sort | roles of mitochondrial fusion and division in harmine derivative h 2 168 induced neurotoxicity |
| url | http://dx.doi.org/10.1155/jimr/6678026 |
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