Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions

Co-administration of nobiletin and tetrahydrocurcumin enhanced the cytotoxicity to breast cancer through inhibiting CYP1A1 enzyme: from the perspective of pharmacokinetic interactions

Abstract Background & objectives The introduction of traditional Chinese medicine to the treatment of breast cancer increases the risk of adverse herb-herb interactions. Both nobiletin and tetrahydrocurcumin (THC) have been demonstrated to inhibit breast cancer progression, which makes them easi...

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Bibliographic Details
Main Authors: Hongming Song, Fengqin Gao, Zhaohe Niu, Xiangping Liu, Xingang Wang, Weihong Cao, Haibo Wang
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Co-administration
Drug-drug interaction
Pharmacokinetic
CYP450
Synergistic effect
Cytotoxicity
Online Access:https://doi.org/10.1007/s12672-025-03229-0
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