Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy

Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy

Introduction Phosphoenolpyruvate carboxykinase 1 (PCK1) is an essential enzyme of the gluconeogenic pathway, which can affect kidney physiology in various ways. Nevertheless, its role in the progression of IgA nephropathy (IgAN) remains to be elucidated.Methods We identified the differentially expre...

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Bibliographic Details
Main Authors: Ya-yin Tan, Yu-kai Wang, Xiao-mei Luo, Chao-yi Chen, Xue-qi Liu, Xin-ran Liu, Yong-gui Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
IgA nephropathy
PCK1
PPARγ
inflammation
fibrosis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2508297
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