Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum?
Hyperemesis gravidarum is a severe manifestation of nausea and vomiting of pregnancy and it is associated with weight loss and metabolic abnormalities. It is known that abnormal laboratory values, including mildly elevated serum lipase level, could be associated with hyperemesis gravidarum. However,...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2015/359239 |
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| author | Amanda Johnson Bethany Cluskey Nina Hooshvar Daphne Tice Courtney Devin Elaine Kao Suhalia Nawabi Steven Jones Lihua Zhang Chi Dola |
| author_facet | Amanda Johnson Bethany Cluskey Nina Hooshvar Daphne Tice Courtney Devin Elaine Kao Suhalia Nawabi Steven Jones Lihua Zhang Chi Dola |
| author_sort | Amanda Johnson |
| collection | DOAJ |
| description | Hyperemesis gravidarum is a severe manifestation of nausea and vomiting of pregnancy and it is associated with weight loss and metabolic abnormalities. It is known that abnormal laboratory values, including mildly elevated serum lipase level, could be associated with hyperemesis gravidarum. However, in this case report details of two women with hyperemesis gravidarum but with significantly elevated serum lipase levels were discussed. These patients presented with severe nausea and vomiting but without abdominal pain. They were found to have severely elevated lipase levels over 1,000 units/liter. In the absence of other findings of pancreatitis, they were treated with conservative measures for hyperemesis gravidarum, with eventual resolution to normal lipase levels. Although significantly elevated lipase level in pregnant patients with nausea and vomiting is a concern for acute pancreatitis, these two cases of significantly elevated serum lipase without other clinical findings of pancreatitis led to this report that serum lipase could be quite elevated in hyperemesis gravidarum and that it might not be an accurate biochemical marker for acute pancreatitis. Imaging studies are thus necessary to establish the diagnosis of acute pancreatitis. |
| format | Article |
| id | doaj-art-eb6bdd8bf9934610abc3d74a2f6d926b |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-eb6bdd8bf9934610abc3d74a2f6d926b2025-02-03T01:30:54ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922015-01-01201510.1155/2015/359239359239Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum?Amanda Johnson0Bethany Cluskey1Nina Hooshvar2Daphne Tice3Courtney Devin4Elaine Kao5Suhalia Nawabi6Steven Jones7Lihua Zhang8Chi Dola9Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, SL-11, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USASection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, SL-11, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USASection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, SL-11, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USASection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, SL-11, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USADepartment of General Surgery, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USASection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, SL-11, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USATulane-Lakeside Hospital, 4700 S I 10 W. Service Road, Metairie, LA 70001, USADepartment of General Surgery, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USADepartment of Anesthesiology, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USASection of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, SL-11, Tulane School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USAHyperemesis gravidarum is a severe manifestation of nausea and vomiting of pregnancy and it is associated with weight loss and metabolic abnormalities. It is known that abnormal laboratory values, including mildly elevated serum lipase level, could be associated with hyperemesis gravidarum. However, in this case report details of two women with hyperemesis gravidarum but with significantly elevated serum lipase levels were discussed. These patients presented with severe nausea and vomiting but without abdominal pain. They were found to have severely elevated lipase levels over 1,000 units/liter. In the absence of other findings of pancreatitis, they were treated with conservative measures for hyperemesis gravidarum, with eventual resolution to normal lipase levels. Although significantly elevated lipase level in pregnant patients with nausea and vomiting is a concern for acute pancreatitis, these two cases of significantly elevated serum lipase without other clinical findings of pancreatitis led to this report that serum lipase could be quite elevated in hyperemesis gravidarum and that it might not be an accurate biochemical marker for acute pancreatitis. Imaging studies are thus necessary to establish the diagnosis of acute pancreatitis.http://dx.doi.org/10.1155/2015/359239 |
| spellingShingle | Amanda Johnson Bethany Cluskey Nina Hooshvar Daphne Tice Courtney Devin Elaine Kao Suhalia Nawabi Steven Jones Lihua Zhang Chi Dola Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum? Case Reports in Obstetrics and Gynecology |
| title | Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum? |
| title_full | Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum? |
| title_fullStr | Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum? |
| title_full_unstemmed | Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum? |
| title_short | Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum? |
| title_sort | significantly elevated serum lipase in pregnancy with nausea and vomiting acute pancreatitis or hyperemesis gravidarum |
| url | http://dx.doi.org/10.1155/2015/359239 |
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