Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Abstract Intracerebral hemorrhage (ICH) is a devastating disease that disrupts the blood–brain barrier (BBB), triggers inflammation, and leads to subsequent neurological deficits. Although the CXC chemokine receptor 3 (CXCR3) and its ligand CXCL10 are implicated in regulating inflammation, the speci...

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Main Authors: Wenqianjun Sheng, Zhangyi Wu, Jingyan Wei, Jun Wang, Shengfan Zhang, Zhiquan Ding, Jinhao Zhong, Dexian Deng, Zhenzhong Zhong, Yunong Yin, Yulong Li, Qinghua Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02658-8
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