Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices
Copper oxide nanoparticles (CuONPs) offer promising antimicrobial properties against a range of pathogens, addressing the urgent issue of antibiotic resistance. This study details the synthesis of glutamic acid-coated CuONPs (GA-CuONPs) and their functionalisation on medical-grade silicone tubing, u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/14/23/1899 |
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| author | James Hall Subbareddy Mekapothula Rebecca Coxhill Dominic Craske Adam M. Varney Gareth W. V. Cave Samantha McLean |
| author_facet | James Hall Subbareddy Mekapothula Rebecca Coxhill Dominic Craske Adam M. Varney Gareth W. V. Cave Samantha McLean |
| author_sort | James Hall |
| collection | DOAJ |
| description | Copper oxide nanoparticles (CuONPs) offer promising antimicrobial properties against a range of pathogens, addressing the urgent issue of antibiotic resistance. This study details the synthesis of glutamic acid-coated CuONPs (GA-CuONPs) and their functionalisation on medical-grade silicone tubing, using an oxysilane bonding agent. The resulting coating shows significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains, while remaining non-toxic to human cells and exhibiting stable adherence, without leaching. This versatile coating method can be applied during manufacturing, or for ad hoc modifications, enhancing the antimicrobial properties of medical devices. |
| format | Article |
| id | doaj-art-eb6997cb49be4ea791fed6d4cea2a2d8 |
| institution | DOAJ |
| issn | 2079-4991 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-eb6997cb49be4ea791fed6d4cea2a2d82025-08-20T02:50:40ZengMDPI AGNanomaterials2079-49912024-11-011423189910.3390/nano14231899Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical DevicesJames Hall0Subbareddy Mekapothula1Rebecca Coxhill2Dominic Craske3Adam M. Varney4Gareth W. V. Cave5Samantha McLean6School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKSchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKSchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKSchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKSchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKSchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKSchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKCopper oxide nanoparticles (CuONPs) offer promising antimicrobial properties against a range of pathogens, addressing the urgent issue of antibiotic resistance. This study details the synthesis of glutamic acid-coated CuONPs (GA-CuONPs) and their functionalisation on medical-grade silicone tubing, using an oxysilane bonding agent. The resulting coating shows significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains, while remaining non-toxic to human cells and exhibiting stable adherence, without leaching. This versatile coating method can be applied during manufacturing, or for ad hoc modifications, enhancing the antimicrobial properties of medical devices.https://www.mdpi.com/2079-4991/14/23/1899copper oxide nanoparticlesESKAPE pathogens3-mercaptopropyltrimethoxysilaneMPTMSantimicrobial activitymulti-drug resistance |
| spellingShingle | James Hall Subbareddy Mekapothula Rebecca Coxhill Dominic Craske Adam M. Varney Gareth W. V. Cave Samantha McLean Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices Nanomaterials copper oxide nanoparticles ESKAPE pathogens 3-mercaptopropyltrimethoxysilane MPTMS antimicrobial activity multi-drug resistance |
| title | Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices |
| title_full | Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices |
| title_fullStr | Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices |
| title_full_unstemmed | Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices |
| title_short | Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices |
| title_sort | surface functionalised copper oxide nanoparticles a pathway to multidrug resistant pathogen control in medical devices |
| topic | copper oxide nanoparticles ESKAPE pathogens 3-mercaptopropyltrimethoxysilane MPTMS antimicrobial activity multi-drug resistance |
| url | https://www.mdpi.com/2079-4991/14/23/1899 |
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