VARIATIONS OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE ACTIVITY IN VARIOUS TISSUES INDUCED BY METABOLIC ALKALOSIS, ACIDOSIS AND DIABETES
The effects of chronic metabolic acidosis, alkalosis and alloxan-induced ketoacidosis on G6PD activity of rat kidney, liver and erythrocytes were studied. Metabolic acidosis significantly increased the activity of kidney enzyme (55%) but decreased the liver (43%) and erythrocyte (38%) enzyme activit...
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| Format: | Article |
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| Language: | English |
| Published: |
University of Tehran
1994-12-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31188_51c5a407dddd1f53b067ea3f25c4b014.pdf |
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| Summary: | The effects of chronic metabolic acidosis, alkalosis and alloxan-induced
ketoacidosis on G6PD activity of rat kidney, liver and erythrocytes were
studied. Metabolic acidosis significantly increased the activity of kidney
enzyme (55%) but decreased the liver (43%) and erythrocyte (38%) enzyme
activities. Alkalosis did not make a significant change in the kidney or liver
enzyme activity but slightly decreased that of the erythrocyte enzyme. In
alloxan-induced diabetic rats, the rise in G6PD activity of kidney (69%) was
associated with a decline in the enzyme activities of liver (50%) and
erythrocytes (51%). It is suggested that in alloxan-induced diabetes,
ketoacidosis is mainly responsible for the change in G6PD activity of various
tissues and different organs do not respond similarly toward metabolic acidosis
or alkalosis. |
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| ISSN: | 1016-1104 2345-6914 |