What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition.
Abstract Background Research and management of juvenile idiopathic arthritis (JIA) are challenging due to its heterogeneous nature, chronicity, and unpredictable, multidimensional long-term outcomes. Main body Long-term studies have consistently shown that a majority of children with JIA reach adult...
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BMC
2025-02-01
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| Series: | Pediatric Rheumatology Online Journal |
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| Online Access: | https://doi.org/10.1186/s12969-025-01070-x |
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| author | Marite Rygg Filipa Oliveira Ramos Ellen Berit Nordal |
| author_facet | Marite Rygg Filipa Oliveira Ramos Ellen Berit Nordal |
| author_sort | Marite Rygg |
| collection | DOAJ |
| description | Abstract Background Research and management of juvenile idiopathic arthritis (JIA) are challenging due to its heterogeneous nature, chronicity, and unpredictable, multidimensional long-term outcomes. Main body Long-term studies have consistently shown that a majority of children with JIA reach adulthood with ongoing disease activity, on medication, or with recurrent flares. The heterogeneity is evident both between and within the present JIA categories based on The International League of Associations for Rheumatology (ILAR) JIA classification system. Several baseline predicting factors are known, but prediction modelling is only in the initial phase, and more models need to be tested in independent cohorts and possibly also supplemented with new biomarkers. Many have criticized the ILAR classification system, but new or updated classification systems have not yet been validated and proved their superiority. The lack of prediction possibilities for long-term outcomes and the limited alignment between JIA classification categories and adult rheumatic conditions are challenges for research, may limit the accessibility to treatment, and hamper a smooth transition to adult care. Conclusion We need more prospective, long-term studies based on unselected JIA cohorts with disease onset in the biologic era that can aid decision-making for individualized early treatment, suggest intervention studies, and ensure our patients the best possible transition to adulthood and the best likelihood of optimal health and quality of life. |
| format | Article |
| id | doaj-art-eb5edcdf5ceb47dd8e85a0a23fe42703 |
| institution | Kabale University |
| issn | 1546-0096 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | Pediatric Rheumatology Online Journal |
| spelling | doaj-art-eb5edcdf5ceb47dd8e85a0a23fe427032025-08-20T03:24:32ZengBMCPediatric Rheumatology Online Journal1546-00962025-02-0123111010.1186/s12969-025-01070-xWhat have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition.Marite Rygg0Filipa Oliveira Ramos1Ellen Berit Nordal2Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences (IKOM), Norwegian University of Science and Technology (NTNU)Pediatric Rheumatology Unit, Hospital Universitário ULS Santa MariaDepartment of Clinical Medicine, The Arctic University of Norway (UiT)Abstract Background Research and management of juvenile idiopathic arthritis (JIA) are challenging due to its heterogeneous nature, chronicity, and unpredictable, multidimensional long-term outcomes. Main body Long-term studies have consistently shown that a majority of children with JIA reach adulthood with ongoing disease activity, on medication, or with recurrent flares. The heterogeneity is evident both between and within the present JIA categories based on The International League of Associations for Rheumatology (ILAR) JIA classification system. Several baseline predicting factors are known, but prediction modelling is only in the initial phase, and more models need to be tested in independent cohorts and possibly also supplemented with new biomarkers. Many have criticized the ILAR classification system, but new or updated classification systems have not yet been validated and proved their superiority. The lack of prediction possibilities for long-term outcomes and the limited alignment between JIA classification categories and adult rheumatic conditions are challenges for research, may limit the accessibility to treatment, and hamper a smooth transition to adult care. Conclusion We need more prospective, long-term studies based on unselected JIA cohorts with disease onset in the biologic era that can aid decision-making for individualized early treatment, suggest intervention studies, and ensure our patients the best possible transition to adulthood and the best likelihood of optimal health and quality of life.https://doi.org/10.1186/s12969-025-01070-xJuvenile idiopathic arthritisAdultOutcomePredictionClassificationTransition |
| spellingShingle | Marite Rygg Filipa Oliveira Ramos Ellen Berit Nordal What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition. Pediatric Rheumatology Online Journal Juvenile idiopathic arthritis Adult Outcome Prediction Classification Transition |
| title | What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition. |
| title_full | What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition. |
| title_fullStr | What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition. |
| title_full_unstemmed | What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition. |
| title_short | What have we learned from long-term studies in juvenile idiopathic arthritis? – Prediction, classification, transition. |
| title_sort | what have we learned from long term studies in juvenile idiopathic arthritis prediction classification transition |
| topic | Juvenile idiopathic arthritis Adult Outcome Prediction Classification Transition |
| url | https://doi.org/10.1186/s12969-025-01070-x |
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