Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind
Abstract Evidence accumulation is a powerful mechanism to explain the temporal dynamics of decisions, as well as their metacognitive components such as confidence judgments and changes of mind. However, it is still unclear how and where in the brain evidence accumulation leads to these two metacogni...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61744-8 |
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| author | Dorian Goueytes François Stockart Alexis Robin Lucien Gyger Martin Rouy Dominique Hoffmann Lorella Minotti Philippe Kahane Michael Pereira Nathan Faivre |
| author_facet | Dorian Goueytes François Stockart Alexis Robin Lucien Gyger Martin Rouy Dominique Hoffmann Lorella Minotti Philippe Kahane Michael Pereira Nathan Faivre |
| author_sort | Dorian Goueytes |
| collection | DOAJ |
| description | Abstract Evidence accumulation is a powerful mechanism to explain the temporal dynamics of decisions, as well as their metacognitive components such as confidence judgments and changes of mind. However, it is still unclear how and where in the brain evidence accumulation leads to these two metacognitive components. We report intracranial high-gamma activity in patients with epilepsy recorded while they perform a visual discrimination task and estimate their confidence level. Our results indicate an anatomical overlap between the neural correlates of evidence accumulation, confidence, and changes of mind in the pre-supplementary motor area, as well as in the orbitofrontal, inferior frontal, and insular cortices. Behavioural and electrophysiological results are reproduced with a post-decisional evidence accumulation model, and the temporal dynamics of decision-making is characterized with mouse-tracking and intracranial electrophysiology. We conclude that confidence and changes of mind result from evidence accumulation, instantiated before the decision in the pre-supplementary motor area, and after the decision in the insula. |
| format | Article |
| id | doaj-art-eb5a35ef848c45249d7b4e1f075fa1ae |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-eb5a35ef848c45249d7b4e1f075fa1ae2025-08-20T03:46:20ZengNature PortfolioNature Communications2041-17232025-07-0116111410.1038/s41467-025-61744-8Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mindDorian Goueytes0François Stockart1Alexis Robin2Lucien Gyger3Martin Rouy4Dominique Hoffmann5Lorella Minotti6Philippe Kahane7Michael Pereira8Nathan Faivre9Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS LPNCUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS LPNCUniversité Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences GINUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS LPNCUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS LPNCDepartment of Neurosurgery, Grenoble HospitalUniversité Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences GINUniversité Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences GINUniversité Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences GINUniversité Grenoble Alpes, Université Savoie Mont Blanc, CNRS LPNCAbstract Evidence accumulation is a powerful mechanism to explain the temporal dynamics of decisions, as well as their metacognitive components such as confidence judgments and changes of mind. However, it is still unclear how and where in the brain evidence accumulation leads to these two metacognitive components. We report intracranial high-gamma activity in patients with epilepsy recorded while they perform a visual discrimination task and estimate their confidence level. Our results indicate an anatomical overlap between the neural correlates of evidence accumulation, confidence, and changes of mind in the pre-supplementary motor area, as well as in the orbitofrontal, inferior frontal, and insular cortices. Behavioural and electrophysiological results are reproduced with a post-decisional evidence accumulation model, and the temporal dynamics of decision-making is characterized with mouse-tracking and intracranial electrophysiology. We conclude that confidence and changes of mind result from evidence accumulation, instantiated before the decision in the pre-supplementary motor area, and after the decision in the insula.https://doi.org/10.1038/s41467-025-61744-8 |
| spellingShingle | Dorian Goueytes François Stockart Alexis Robin Lucien Gyger Martin Rouy Dominique Hoffmann Lorella Minotti Philippe Kahane Michael Pereira Nathan Faivre Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind Nature Communications |
| title | Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind |
| title_full | Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind |
| title_fullStr | Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind |
| title_full_unstemmed | Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind |
| title_short | Evidence accumulation in the pre-supplementary motor area and insula drives confidence and changes of mind |
| title_sort | evidence accumulation in the pre supplementary motor area and insula drives confidence and changes of mind |
| url | https://doi.org/10.1038/s41467-025-61744-8 |
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