Second primary malignancies of cancer patients: treatment-related carcinogenesis
Cytostatic drugs used in chemotherapy cause secondary tumors in some patients cured of the antecedent neoplasm. Thus the incidence of second neoplasia for cancer survivors compared with the general population represents a 4-fold to 6-fold increased risk.The review presents recent data on the mechani...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2016-09-01
|
| Series: | Успехи молекулярной онкологии |
| Subjects: | |
| Online Access: | https://umo.abvpress.ru/jour/article/view/69 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850025005890404352 |
|---|---|
| author | G. A. Belitskiy E. A. Lesovaya K. I. Kirsanov M. G. Yakubovskaya |
| author_facet | G. A. Belitskiy E. A. Lesovaya K. I. Kirsanov M. G. Yakubovskaya |
| author_sort | G. A. Belitskiy |
| collection | DOAJ |
| description | Cytostatic drugs used in chemotherapy cause secondary tumors in some patients cured of the antecedent neoplasm. Thus the incidence of second neoplasia for cancer survivors compared with the general population represents a 4-fold to 6-fold increased risk.The review presents recent data on the mechanisms of malignant transformation of cells by cytostatics, on the characteristics of high- risk groups associated with congenital polymorphisms of xenobiotic metabolizing enzymes and DNA repair systems. Increased risk of drug-related cancer was observed in patients with high activity of P450 isoforms, transforming cytotoxic prodrugs into the active electrophilic metabolites and low level of detoxifying enzymes. All things being equal the risk of therapy related neoplasia is higher in patients with low activity of DNA repair enzymes. It is evaluated the possibility of experimental study of new targeted drugs carcinogenic potential in order to minimize the future risk of secondary malignancies. |
| format | Article |
| id | doaj-art-eb578386f8764cc7b3cefb491c62bf5b |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2016-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-eb578386f8764cc7b3cefb491c62bf5b2025-08-20T03:00:58ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872016-09-0133445510.17650/2313-805X-2016-3-3-44-5565Second primary malignancies of cancer patients: treatment-related carcinogenesisG. A. Belitskiy0E. A. Lesovaya1K. I. Kirsanov2M. G. Yakubovskaya3Research Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Reseach Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaResearch Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Reseach Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, Russia I.P. Pavlov Ryazan’ State Medical University, Ministry of Health of Russia; 9 Vasokovol’tnaya St., Ryazan’, 390026, RussiaResearch Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Reseach Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaResearch Institute of Carcinogenesis, N.N. Blokhin Russian Cancer Reseach Center, Ministry of Health of Russia; 24 Kashirskoe Shosse, Moscow, 115478, RussiaCytostatic drugs used in chemotherapy cause secondary tumors in some patients cured of the antecedent neoplasm. Thus the incidence of second neoplasia for cancer survivors compared with the general population represents a 4-fold to 6-fold increased risk.The review presents recent data on the mechanisms of malignant transformation of cells by cytostatics, on the characteristics of high- risk groups associated with congenital polymorphisms of xenobiotic metabolizing enzymes and DNA repair systems. Increased risk of drug-related cancer was observed in patients with high activity of P450 isoforms, transforming cytotoxic prodrugs into the active electrophilic metabolites and low level of detoxifying enzymes. All things being equal the risk of therapy related neoplasia is higher in patients with low activity of DNA repair enzymes. It is evaluated the possibility of experimental study of new targeted drugs carcinogenic potential in order to minimize the future risk of secondary malignancies.https://umo.abvpress.ru/jour/article/view/69chemotherapy-induced carcinogenesissecond primary tumorchemotherapy drug metabolismtopoisomerase inhibitoralkylating agent |
| spellingShingle | G. A. Belitskiy E. A. Lesovaya K. I. Kirsanov M. G. Yakubovskaya Second primary malignancies of cancer patients: treatment-related carcinogenesis Успехи молекулярной онкологии chemotherapy-induced carcinogenesis second primary tumor chemotherapy drug metabolism topoisomerase inhibitor alkylating agent |
| title | Second primary malignancies of cancer patients: treatment-related carcinogenesis |
| title_full | Second primary malignancies of cancer patients: treatment-related carcinogenesis |
| title_fullStr | Second primary malignancies of cancer patients: treatment-related carcinogenesis |
| title_full_unstemmed | Second primary malignancies of cancer patients: treatment-related carcinogenesis |
| title_short | Second primary malignancies of cancer patients: treatment-related carcinogenesis |
| title_sort | second primary malignancies of cancer patients treatment related carcinogenesis |
| topic | chemotherapy-induced carcinogenesis second primary tumor chemotherapy drug metabolism topoisomerase inhibitor alkylating agent |
| url | https://umo.abvpress.ru/jour/article/view/69 |
| work_keys_str_mv | AT gabelitskiy secondprimarymalignanciesofcancerpatientstreatmentrelatedcarcinogenesis AT ealesovaya secondprimarymalignanciesofcancerpatientstreatmentrelatedcarcinogenesis AT kikirsanov secondprimarymalignanciesofcancerpatientstreatmentrelatedcarcinogenesis AT mgyakubovskaya secondprimarymalignanciesofcancerpatientstreatmentrelatedcarcinogenesis |