Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors

Abstract Nicotine activates ventral tegmental area (VTA) dopaminergic (DA) neurons projecting to the nucleus accumbens (NAc) to drive its reinforcing effects. Simultaneously, nicotine inhibits those projecting to the amygdala (Amg) to mediate anxiety-like behavior through a process that remains unkn...

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Bibliographic Details
Main Authors: Tïnaïg Le Borgne, Claire Nguyen, Eléonore Vicq, Joachim Jehl, Clément Solié, Nicolas Guyon, Louison Daussy, Aylin Gulmez, Lauren M. Reynolds, Sarah Mondoloni, Stéfania Tolu, Stéphanie Pons, Uwe Maskos, Emmanuel Valjent, Alexandre Mourot, Philippe Faure, Fabio Marti
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61180-8
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