Primary pancreatic signet ring cell carcinoma: a case series from China and literature review
Abstract Objective To report on cases of primary pancreatic signet ring cell carcinoma (PSRCC) from our institution, review the published literature, and evaluate the clinicopathological characteristics. Material and methods We present a recent case of PSRCC and report 11 additional cases from China...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-025-02504-4 |
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| author | Dongming Zhang Tianyu Li Bo Chen Georgios Antonios Margonis Jaeyun Jane Wang Jiashu Han Kaiqi Ma Rilige Chaomu Chen Lin Weibin Wang |
| author_facet | Dongming Zhang Tianyu Li Bo Chen Georgios Antonios Margonis Jaeyun Jane Wang Jiashu Han Kaiqi Ma Rilige Chaomu Chen Lin Weibin Wang |
| author_sort | Dongming Zhang |
| collection | DOAJ |
| description | Abstract Objective To report on cases of primary pancreatic signet ring cell carcinoma (PSRCC) from our institution, review the published literature, and evaluate the clinicopathological characteristics. Material and methods We present a recent case of PSRCC and report 11 additional cases from China, utilizing the China National Knowledge Infrastructure (CNKI) database. The literature search encompassed publications from January 1994 to December 2023. We also performed a literature search using PubMed and Web of Science to identify cases of PSRCC outside of China and identified a total of 13 additional cases. Results A total of 12 cases from China were identified, with a mean age of 64 years. Among these, 11 patients (91.7%) were male, and 1 patient (8.3%) was female. The tumor was primarily located in the pancreatic head (7 cases, 57.3%), followed by the pancreatic body (3 cases, 25.0%) and tail (2 cases, 16.7%). Six patients (50%) underwent radical curative surgery, while the remaining 6 (50%) received palliative surgical treatment or chemotherapy. In the radical curative surgery group (6 patients), the longest follow-up was 23 months, with only one death reported. In contrast, all patients who received palliative treatment (6 patients) experienced short-term mortality, with the longest follow-up period being 5 months. While most patients were Chinese, similar outcomes have been reported in non-Chinese populations, indicating broader applicability. Conclusion PSRCC is a highly aggressive and extremely rare pancreatic malignancy, typically originating in the head of the pancreas. Patients diagnosed at an early stage and who undergo radical surgery demonstrate significantly prolonged survival. |
| format | Article |
| id | doaj-art-eb4e63bab40d4ad58f772b32a8293f99 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-eb4e63bab40d4ad58f772b32a8293f992025-08-20T01:51:39ZengSpringerDiscover Oncology2730-60112025-05-011611910.1007/s12672-025-02504-4Primary pancreatic signet ring cell carcinoma: a case series from China and literature reviewDongming Zhang0Tianyu Li1Bo Chen2Georgios Antonios Margonis3Jaeyun Jane Wang4Jiashu Han5Kaiqi Ma6Rilige Chaomu7Chen Lin8Weibin Wang9Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, University of California San FranciscoDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of General Surgery, Central Clinical Medical College of Baotou Medical College, Inner Mongolia University of Science and TechnologyDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesDepartment of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesAbstract Objective To report on cases of primary pancreatic signet ring cell carcinoma (PSRCC) from our institution, review the published literature, and evaluate the clinicopathological characteristics. Material and methods We present a recent case of PSRCC and report 11 additional cases from China, utilizing the China National Knowledge Infrastructure (CNKI) database. The literature search encompassed publications from January 1994 to December 2023. We also performed a literature search using PubMed and Web of Science to identify cases of PSRCC outside of China and identified a total of 13 additional cases. Results A total of 12 cases from China were identified, with a mean age of 64 years. Among these, 11 patients (91.7%) were male, and 1 patient (8.3%) was female. The tumor was primarily located in the pancreatic head (7 cases, 57.3%), followed by the pancreatic body (3 cases, 25.0%) and tail (2 cases, 16.7%). Six patients (50%) underwent radical curative surgery, while the remaining 6 (50%) received palliative surgical treatment or chemotherapy. In the radical curative surgery group (6 patients), the longest follow-up was 23 months, with only one death reported. In contrast, all patients who received palliative treatment (6 patients) experienced short-term mortality, with the longest follow-up period being 5 months. While most patients were Chinese, similar outcomes have been reported in non-Chinese populations, indicating broader applicability. Conclusion PSRCC is a highly aggressive and extremely rare pancreatic malignancy, typically originating in the head of the pancreas. Patients diagnosed at an early stage and who undergo radical surgery demonstrate significantly prolonged survival.https://doi.org/10.1007/s12672-025-02504-4 |
| spellingShingle | Dongming Zhang Tianyu Li Bo Chen Georgios Antonios Margonis Jaeyun Jane Wang Jiashu Han Kaiqi Ma Rilige Chaomu Chen Lin Weibin Wang Primary pancreatic signet ring cell carcinoma: a case series from China and literature review Discover Oncology |
| title | Primary pancreatic signet ring cell carcinoma: a case series from China and literature review |
| title_full | Primary pancreatic signet ring cell carcinoma: a case series from China and literature review |
| title_fullStr | Primary pancreatic signet ring cell carcinoma: a case series from China and literature review |
| title_full_unstemmed | Primary pancreatic signet ring cell carcinoma: a case series from China and literature review |
| title_short | Primary pancreatic signet ring cell carcinoma: a case series from China and literature review |
| title_sort | primary pancreatic signet ring cell carcinoma a case series from china and literature review |
| url | https://doi.org/10.1007/s12672-025-02504-4 |
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