Inflammasomes in Human Immunodeficiency Virus Type 1 Infection
Abstract. Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucle...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2022-10-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000070 |
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| _version_ | 1850210246560055296 |
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| author | Qiankun Wang Liang Shan |
| author_facet | Qiankun Wang Liang Shan |
| author_sort | Qiankun Wang |
| collection | DOAJ |
| description | Abstract. Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucleic acids or proteins, some pattern recognition receptors have the ability to assemble a large multiprotein complex called the inflammasome, which triggers pro-inflammatory cytokine release and a form of lytic programmed cell death called pyroptosis. Here, we review our current understanding of the mechanism of the inflammasome in sensing HIV-1 infection. Furthermore, we discuss the contribution of inflammasome activation in HIV-1 pathogenesis as well as potential strategies of targeting inflammasome activation for the treatment of HIV-1 infection. |
| format | Article |
| id | doaj-art-eb4c755507ce4554856dc1eb7beebdf3 |
| institution | OA Journals |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-eb4c755507ce4554856dc1eb7beebdf32025-08-20T02:09:48ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392022-10-012424825210.1097/ID9.0000000000000070202210000-00007Inflammasomes in Human Immunodeficiency Virus Type 1 InfectionQiankun Wang0Liang Shan1Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.Abstract. Innate immune responses are the host's first line of defense against human immunodeficiency virus type 1 (HIV-1) infection, with pattern recognition receptors detecting viral specific pathogen-associated molecular patterns and initiating antiviral responses. In response to HIV-1 nucleic acids or proteins, some pattern recognition receptors have the ability to assemble a large multiprotein complex called the inflammasome, which triggers pro-inflammatory cytokine release and a form of lytic programmed cell death called pyroptosis. Here, we review our current understanding of the mechanism of the inflammasome in sensing HIV-1 infection. Furthermore, we discuss the contribution of inflammasome activation in HIV-1 pathogenesis as well as potential strategies of targeting inflammasome activation for the treatment of HIV-1 infection.http://journals.lww.com/10.1097/ID9.0000000000000070 |
| spellingShingle | Qiankun Wang Liang Shan Inflammasomes in Human Immunodeficiency Virus Type 1 Infection Infectious Diseases & Immunity |
| title | Inflammasomes in Human Immunodeficiency Virus Type 1 Infection |
| title_full | Inflammasomes in Human Immunodeficiency Virus Type 1 Infection |
| title_fullStr | Inflammasomes in Human Immunodeficiency Virus Type 1 Infection |
| title_full_unstemmed | Inflammasomes in Human Immunodeficiency Virus Type 1 Infection |
| title_short | Inflammasomes in Human Immunodeficiency Virus Type 1 Infection |
| title_sort | inflammasomes in human immunodeficiency virus type 1 infection |
| url | http://journals.lww.com/10.1097/ID9.0000000000000070 |
| work_keys_str_mv | AT qiankunwang inflammasomesinhumanimmunodeficiencyvirustype1infection AT liangshan inflammasomesinhumanimmunodeficiencyvirustype1infection |