Lymphoproliferative neoplasms and renal cell carcinoma of clear cell type - where is the link?
Introduction. The etiology of higher than expected occurrence of lymphoproliferative neoplasms (LPN) and renal cell carcinoma (RCC) in the same patient has not yet been clarified. Several explanations for this co-occurrence have been postulated: prior cytotoxic treatment, viral infection...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500054C.pdf |
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| Summary: | Introduction. The etiology of higher than expected occurrence of
lymphoproliferative neoplasms (LPN) and renal cell carcinoma (RCC) in the
same patient has not yet been clarified. Several explanations for this
co-occurrence have been postulated: prior cytotoxic treatment, viral
infections, immunomodulatory effects of tumor itself and shared genetic
and/or environmental factors. Case report. Medical records of 680 consecutive
patients with LPN and 570 consecutive patients with RCC diagnosed between
January 1997 and December 2011 in two centers were retrospectively analyzed.
Co-occurrence of both diseases was registered in five of the patients (3
males, 2 females) and their demographic, clinical and pathological
characteristics were presented. Conclusion. Synchronous occurrence of LPN
neoplasms and RCC or a short latent period between the diagnoses of these two
malignancies in the same patient, as well as the lack of cytotoxic treatment
for firstly occurring neoplasm implies a possible common pathobiology of both
diseases. |
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| ISSN: | 0042-8450 2406-0720 |