Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol)

Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol)

This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and...

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Bibliographic Details
Main Authors: Judit Eva Puskas, Enikő Krisch, Aswathy Sasidharan Pillai, Prajakatta Mulay
Format: Article
Language:English
Published: Budapest University of Technology and Economics 2022-09-01
Series:eXPRESS Polymer Letters
Subjects:
polymer synthesis, molecular engineering
tailor-made polymers
biocompatible polymers
poly(ethylene glycol) diamine
enzyme catalysis
Online Access:http://www.expresspolymlett.com/letolt.php?file=EPL-0011841&mi=cd
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Summary:This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and MALDI-ToF demonstrated the purity of the product. After deprotection, the desired diamine-functionalized PEG was obtained. Protected L-Alanine did not reach full conversion by NMR, likely due to the steric hindrance of its methyl side group.
ISSN:1788-618X

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