Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats
Endotoxemia induces a series of inflammatory responses that may result in lung injury. However, heat shock protein72 (HSP72) has the potential to protect the lungs from damage. The objective of this study was to determine whether prior exercise conditioning could increase the expression of HSP72 in...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/527090 |
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| author | Ching-Hsia Hung Jann-Inn Tzeng Che-Ning Chang Yu-Wen Chen Chia-Ying Cho Jhi-Joung Wang |
| author_facet | Ching-Hsia Hung Jann-Inn Tzeng Che-Ning Chang Yu-Wen Chen Chia-Ying Cho Jhi-Joung Wang |
| author_sort | Ching-Hsia Hung |
| collection | DOAJ |
| description | Endotoxemia induces a series of inflammatory responses that may result in lung injury. However, heat shock protein72 (HSP72) has the potential to protect the lungs from damage. The objective of this study was to determine whether prior exercise conditioning could increase the expression of HSP72 in the lungs and attenuate lung damage in diabetic rats receiving lipopolysaccharide (LPS). Streptozotocin was used to induce diabetes in adult male Wistar rats. Rats were randomly assigned to sedentary or exercise groups. Rats in the exercise condition ran on a treadmill 5 days/week, 30–60 min/day, with an intensity of 1.0 mile/hour over a 3-week period. Rats received an intravenous infusion of LPS after 24 hrs from the last training session. Elevated lavage tumor necrosis factor-alpha (TNF-α) level in response to LPS was more marked in diabetic rats. HSP72 expression in lungs was significantly increased after exercise conditioning, but less pronounced in diabetic rats. After administration of LPS, exercised rats displayed higher survival rate as well as decreased lavage TNF-α level and lung edema in comparison to sedentary rats. Our findings suggest that exercise conditioning could attenuate the occurrence of inflammatory responses and lung damage, thereby reducing mortality rate in diabetic rats during endotoxemia. |
| format | Article |
| id | doaj-art-eb478edf87254cf490f3addcd778958a |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-eb478edf87254cf490f3addcd778958a2025-08-20T02:22:21ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/527090527090Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic RatsChing-Hsia Hung0Jann-Inn Tzeng1Che-Ning Chang2Yu-Wen Chen3Chia-Ying Cho4Jhi-Joung Wang5Department of Physical Therapy, National Cheng Kung University, Tainan 701, TaiwanDepartment of Food Sciences and Technology, Chia Nan University of Pharmacy and Sciences, Jen-Te, Tainan 717, TaiwanDepartment of Physical Therapy, National Cheng Kung University, Tainan 701, TaiwanDepartment of Physical Therapy, China Medical University, Taichung 404, TaiwanDepartment of Physical Therapy, National Cheng Kung University, Tainan 701, TaiwanDepartment of Medical Research, Chi-Mei Medical Centre, Tainan 710, TaiwanEndotoxemia induces a series of inflammatory responses that may result in lung injury. However, heat shock protein72 (HSP72) has the potential to protect the lungs from damage. The objective of this study was to determine whether prior exercise conditioning could increase the expression of HSP72 in the lungs and attenuate lung damage in diabetic rats receiving lipopolysaccharide (LPS). Streptozotocin was used to induce diabetes in adult male Wistar rats. Rats were randomly assigned to sedentary or exercise groups. Rats in the exercise condition ran on a treadmill 5 days/week, 30–60 min/day, with an intensity of 1.0 mile/hour over a 3-week period. Rats received an intravenous infusion of LPS after 24 hrs from the last training session. Elevated lavage tumor necrosis factor-alpha (TNF-α) level in response to LPS was more marked in diabetic rats. HSP72 expression in lungs was significantly increased after exercise conditioning, but less pronounced in diabetic rats. After administration of LPS, exercised rats displayed higher survival rate as well as decreased lavage TNF-α level and lung edema in comparison to sedentary rats. Our findings suggest that exercise conditioning could attenuate the occurrence of inflammatory responses and lung damage, thereby reducing mortality rate in diabetic rats during endotoxemia.http://dx.doi.org/10.1155/2013/527090 |
| spellingShingle | Ching-Hsia Hung Jann-Inn Tzeng Che-Ning Chang Yu-Wen Chen Chia-Ying Cho Jhi-Joung Wang Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats Journal of Diabetes Research |
| title | Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats |
| title_full | Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats |
| title_fullStr | Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats |
| title_full_unstemmed | Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats |
| title_short | Treadmill Exercise Preconditioning Attenuates Lung Damage Caused by Systemic Endotoxemia in Type 1 Diabetic Rats |
| title_sort | treadmill exercise preconditioning attenuates lung damage caused by systemic endotoxemia in type 1 diabetic rats |
| url | http://dx.doi.org/10.1155/2013/527090 |
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