From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities
The transverse–axial tubular system (TATS) is the extension of sarcolemma growing to the cell interior, providing sufficient calcium signaling to induce calcium release from sarcoplasmic reticulum cisternae and stimulate the contraction of neighboring myofibrils. Interestingly, the development of TA...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1576133/full |
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| author | Zuzana Sevcikova Tomaskova Katarina Mackova |
| author_facet | Zuzana Sevcikova Tomaskova Katarina Mackova |
| author_sort | Zuzana Sevcikova Tomaskova |
| collection | DOAJ |
| description | The transverse–axial tubular system (TATS) is the extension of sarcolemma growing to the cell interior, providing sufficient calcium signaling to induce calcium release from sarcoplasmic reticulum cisternae and stimulate the contraction of neighboring myofibrils. Interestingly, the development of TATS is delayed and matures during the post-partum period. It starts with small invaginations near the sarcolemma, proceeding to grow an irregular network that is later assembled into the notably transversally oriented tubular network. Accumulating evidence supports the idea that the development of TATS is linked to cell dimensions, calcium signaling, and increasing myofibrillar content orchestrated by electromechanical stimulation. However, the overall mechanism has not yet been described. The topic of this review is the development of TATS with an emphasis on the irregular phase of tubule growth. The traditional models of BIN1-related tubulation are also discussed. We summarized the recently described protein interactions during TATS development, mainly mediated by costameric and sarcomeric proteins, supporting the idea of the coupling sites between TATS and the myofibrils. We hypothesize that the formation and final organization of the tubular system is driven by the simultaneous development of the contractile apparatus under cycling electromechanical stimulus. |
| format | Article |
| id | doaj-art-eb46b42925d84c2e808e87da857093d4 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-eb46b42925d84c2e808e87da857093d42025-08-20T03:14:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-04-011610.3389/fphys.2025.15761331576133From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiaritiesZuzana Sevcikova TomaskovaKatarina MackovaThe transverse–axial tubular system (TATS) is the extension of sarcolemma growing to the cell interior, providing sufficient calcium signaling to induce calcium release from sarcoplasmic reticulum cisternae and stimulate the contraction of neighboring myofibrils. Interestingly, the development of TATS is delayed and matures during the post-partum period. It starts with small invaginations near the sarcolemma, proceeding to grow an irregular network that is later assembled into the notably transversally oriented tubular network. Accumulating evidence supports the idea that the development of TATS is linked to cell dimensions, calcium signaling, and increasing myofibrillar content orchestrated by electromechanical stimulation. However, the overall mechanism has not yet been described. The topic of this review is the development of TATS with an emphasis on the irregular phase of tubule growth. The traditional models of BIN1-related tubulation are also discussed. We summarized the recently described protein interactions during TATS development, mainly mediated by costameric and sarcomeric proteins, supporting the idea of the coupling sites between TATS and the myofibrils. We hypothesize that the formation and final organization of the tubular system is driven by the simultaneous development of the contractile apparatus under cycling electromechanical stimulus.https://www.frontiersin.org/articles/10.3389/fphys.2025.1576133/fullt-tubulestransverse–axial tubular systempostnatal developmentcardiomyocytesarcomereZ-line |
| spellingShingle | Zuzana Sevcikova Tomaskova Katarina Mackova From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities Frontiers in Physiology t-tubules transverse–axial tubular system postnatal development cardiomyocyte sarcomere Z-line |
| title | From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities |
| title_full | From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities |
| title_fullStr | From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities |
| title_full_unstemmed | From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities |
| title_short | From function to structure: how myofibrillogenesis influences the transverse–axial tubular system development and its peculiarities |
| title_sort | from function to structure how myofibrillogenesis influences the transverse axial tubular system development and its peculiarities |
| topic | t-tubules transverse–axial tubular system postnatal development cardiomyocyte sarcomere Z-line |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1576133/full |
| work_keys_str_mv | AT zuzanasevcikovatomaskova fromfunctiontostructurehowmyofibrillogenesisinfluencesthetransverseaxialtubularsystemdevelopmentanditspeculiarities AT katarinamackova fromfunctiontostructurehowmyofibrillogenesisinfluencesthetransverseaxialtubularsystemdevelopmentanditspeculiarities |