Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8

Novel polycyclic meroterpenoids with protein tyrosine phosphatase 1B inhibitory activity isolated from desert-derived fungi Talaromyces sp. HMT-8

Abstract Seven previously undescribed polycyclic meroterpenoids talarines K–Q (1–7), along with five known ones (8–12), were isolated from desert-derived fungi Talaromyces sp. HMT-8. The structure of the novel compounds were elucidated using spectroscopic methods, including electronic circular dichr...

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Bibliographic Details
Main Authors: Xin-yi Zhai, Jin-jie Liu, Cui-duan Wang, Yi-fan Dou, Jian-hua Lv, Li-an Wang, Jin-xiu Zhang, Zhuang Li
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Natural Products and Bioprospecting
Subjects:
Talaromyces sp.
Polycyclic meroterpenoids
PTP1B
Enzyme kinetics
Molecular docking
Online Access:https://doi.org/10.1007/s13659-025-00530-x
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