The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy
Background: The aim of this retrospective study was to investigate the importance of leukocyte, neutrophil, lymphocyte, and neutrophil/lymphocyte (NLR) ratios in epileptic seizure recurrence and whether there is a relationship between them. Objectives: To evaluate the predictive value of leukocyte,...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Acta Neurologica Taiwanica |
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| Online Access: | https://journals.lww.com/10.4103/ANT.ANT_112_0107 |
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| author | Elif Simin Issı Demet İlhan Algın Oğuz Osman Erdinç |
| author_facet | Elif Simin Issı Demet İlhan Algın Oğuz Osman Erdinç |
| author_sort | Elif Simin Issı |
| collection | DOAJ |
| description | Background:
The aim of this retrospective study was to investigate the importance of leukocyte, neutrophil, lymphocyte, and neutrophil/lymphocyte (NLR) ratios in epileptic seizure recurrence and whether there is a relationship between them.
Objectives:
To evaluate the predictive value of leukocyte, neutrophil, lymphocyte, and monocyte parameters in assessing the likelihood of seizure recurrence in epilepsy patients.
Materials and Methods:
Sixty-five epilepsy patients who were on follow-up for epilepsy were included in the study. The study group consisted of epilepsy patients who had routine complete blood counts taken within the first 24 hours of emergency room visits due to seizures and for control purposes at outpatient clinic visits. The parameters examined were leukocyte, neutrophil, lymphocyte, platelet counts (PLT) (×10³ mm³), mean platelet volume (MPV), and NLR. NLR was calculated by dividing the absolute number of neutrophils by the absolute number of lymphocytes.
Results:
Leukocyte, neutrophil, NLR, and monocyte values (P < 0.001) were significantly higher in patients with seizure recurrence in the first 30 days compared to those without recurrence. The predictive value of leukocyte, neutrophil, NLR, and monocyte parameters for seizure recurrence was assessed using receiver operating characteristic (ROC) analysis. Since the area under the curve (AUC) value for NLR was larger than that of neutrophil and monocyte values, the diagnostic performance of NLR was found to be superior. For NLR, the AUC value was 0.73 (95% confidence interval: 0.639–0.807, P = 0.0001), with sensitivity and specificity of 52.31% and 94.23%, respectively. NLR had the highest predictive value for seizure recurrence.
Conclusions:
Our study suggests that neutrophil-mediated inflammation plays a role in epileptic seizures and that monocyte values are also important. NLR and monocyte values may serve as predictive biomarkers for seizure recurrence. |
| format | Article |
| id | doaj-art-eb44df3e435d48ddb285886fb80b8fd9 |
| institution | OA Journals |
| issn | 1028-768X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Acta Neurologica Taiwanica |
| spelling | doaj-art-eb44df3e435d48ddb285886fb80b8fd92025-08-20T02:32:31ZengWolters Kluwer Medknow PublicationsActa Neurologica Taiwanica1028-768X2025-01-01341202310.4103/ANT.ANT_112_0107The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with EpilepsyElif Simin IssıDemet İlhan AlgınOğuz Osman ErdinçBackground: The aim of this retrospective study was to investigate the importance of leukocyte, neutrophil, lymphocyte, and neutrophil/lymphocyte (NLR) ratios in epileptic seizure recurrence and whether there is a relationship between them. Objectives: To evaluate the predictive value of leukocyte, neutrophil, lymphocyte, and monocyte parameters in assessing the likelihood of seizure recurrence in epilepsy patients. Materials and Methods: Sixty-five epilepsy patients who were on follow-up for epilepsy were included in the study. The study group consisted of epilepsy patients who had routine complete blood counts taken within the first 24 hours of emergency room visits due to seizures and for control purposes at outpatient clinic visits. The parameters examined were leukocyte, neutrophil, lymphocyte, platelet counts (PLT) (×10³ mm³), mean platelet volume (MPV), and NLR. NLR was calculated by dividing the absolute number of neutrophils by the absolute number of lymphocytes. Results: Leukocyte, neutrophil, NLR, and monocyte values (P < 0.001) were significantly higher in patients with seizure recurrence in the first 30 days compared to those without recurrence. The predictive value of leukocyte, neutrophil, NLR, and monocyte parameters for seizure recurrence was assessed using receiver operating characteristic (ROC) analysis. Since the area under the curve (AUC) value for NLR was larger than that of neutrophil and monocyte values, the diagnostic performance of NLR was found to be superior. For NLR, the AUC value was 0.73 (95% confidence interval: 0.639–0.807, P = 0.0001), with sensitivity and specificity of 52.31% and 94.23%, respectively. NLR had the highest predictive value for seizure recurrence. Conclusions: Our study suggests that neutrophil-mediated inflammation plays a role in epileptic seizures and that monocyte values are also important. NLR and monocyte values may serve as predictive biomarkers for seizure recurrence.https://journals.lww.com/10.4103/ANT.ANT_112_0107inflammationneutrophil-to-lymphocyte ratiorecurrencesseizures |
| spellingShingle | Elif Simin Issı Demet İlhan Algın Oğuz Osman Erdinç The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy Acta Neurologica Taiwanica inflammation neutrophil-to-lymphocyte ratio recurrences seizures |
| title | The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy |
| title_full | The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy |
| title_fullStr | The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy |
| title_full_unstemmed | The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy |
| title_short | The Predictive Role of Neutrophil-to-LymPhocyte Ratio in Seizure Recurrence in Patients with Epilepsy |
| title_sort | predictive role of neutrophil to lymphocyte ratio in seizure recurrence in patients with epilepsy |
| topic | inflammation neutrophil-to-lymphocyte ratio recurrences seizures |
| url | https://journals.lww.com/10.4103/ANT.ANT_112_0107 |
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