Interleukin-4 induces CD11c+ microglia leading to amelioration of neuropathic pain in mice

Interleukin-4 induces CD11c+ microglia leading to amelioration of neuropathic pain in mice

Neuropathic pain, a debilitating chronic pain condition, is a major clinical challenge. The pleiotropic cytokine interleukin-4 (IL-4) has been shown to suppress neuropathic pain in rodent models, but its underlying mechanism remains unclear. Here, we show that intrathecal administration of IL-4 to m...

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Bibliographic Details
Main Authors: Keita Kohno, Ryoji Shirasaka, Keita Hirose, Takahiro Masuda, Makoto Tsuda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
neuropathic pain
microglia
spinal cord
interleukin4
Online Access:https://elifesciences.org/articles/105087
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