Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress
Background: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms. Objective: To explore the association between Osteopontin, oxidative stress, and antioxidant capacity in hypothyroi...
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| Format: | Article |
| Language: | English |
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Universitas Padjadjaran
2025-04-01
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| Series: | International Journal of Integrated Health Sciences |
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| Online Access: | https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4099 |
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| author | Sumesh Prasad Sah Sonu Sah Sudeep Kumar Manisha Arora Dinesh Kumar Raj Kumar |
| author_facet | Sumesh Prasad Sah Sonu Sah Sudeep Kumar Manisha Arora Dinesh Kumar Raj Kumar |
| author_sort | Sumesh Prasad Sah |
| collection | DOAJ |
| description | Background: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms.
Objective: To explore the association between Osteopontin, oxidative stress, and antioxidant capacity in hypothyroid woman with or without anemia.
Methods: The study was conducted at the Santosh Medical College Department of Biochemistry in Ghaziabad, India, from September 2019 to October 2021. This study was cross-sectional and recruited 360 female subjects, divided into three groups: hypothyroidism with anemia, hypothyroidism without anemia, and normal healthy controls. Osteopontin, thyroid profile, malondialdehyde (MDA) and total antioxidant capacity were measured.
Results: Osteopontin, T3, T4, and total antioxidant capacity levels were significantly lower (p<0.001), and the TSH and MDA levels significantly increased (p<0.001) in female subjects experiencing hypothyroidism, with or without anemia, as compared to normal healthy female control groups. Osteopontin demonstrated significant negative relationship with TSH and MDA, while showing a significant positive relationship with T3, T4, and total antioxidant status in both studied groups.
Conclusion: Osteopontin and oxidative stress/antioxidant status significantly correlate in female subjects experiencing hypothyroidism, with or without anemia. In these patients, Osteopontin might be a useful biomarker for evaluating antioxidant levels and oxidative stress. |
| format | Article |
| id | doaj-art-eb3f8bfcbe1f437fad21946fed77603a |
| institution | Kabale University |
| issn | 2302-1381 2338-4506 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | International Journal of Integrated Health Sciences |
| spelling | doaj-art-eb3f8bfcbe1f437fad21946fed77603a2025-08-20T03:58:11ZengUniversitas PadjadjaranInternational Journal of Integrated Health Sciences2302-13812338-45062025-04-01131172110.15850/ijihs.v13n1.40991837Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative StressSumesh Prasad Sah0Sonu Sah1Sudeep Kumar2Manisha Arora3Dinesh Kumar4Raj Kumar5Biochemistry Department, Muzaffarnagar Medical College, MuzaffarnagarMuzaffarnagar Nursing Institute, MuzaffarnagarMuzaffarnagar Medical College, MuzaffarnagarMercer University School of Medicine, GeorgiaMuzaffarnagar Medical College, MuzaffarnagarMuzaffarnagar Medical College, MuzaffarnagarBackground: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms. Objective: To explore the association between Osteopontin, oxidative stress, and antioxidant capacity in hypothyroid woman with or without anemia. Methods: The study was conducted at the Santosh Medical College Department of Biochemistry in Ghaziabad, India, from September 2019 to October 2021. This study was cross-sectional and recruited 360 female subjects, divided into three groups: hypothyroidism with anemia, hypothyroidism without anemia, and normal healthy controls. Osteopontin, thyroid profile, malondialdehyde (MDA) and total antioxidant capacity were measured. Results: Osteopontin, T3, T4, and total antioxidant capacity levels were significantly lower (p<0.001), and the TSH and MDA levels significantly increased (p<0.001) in female subjects experiencing hypothyroidism, with or without anemia, as compared to normal healthy female control groups. Osteopontin demonstrated significant negative relationship with TSH and MDA, while showing a significant positive relationship with T3, T4, and total antioxidant status in both studied groups. Conclusion: Osteopontin and oxidative stress/antioxidant status significantly correlate in female subjects experiencing hypothyroidism, with or without anemia. In these patients, Osteopontin might be a useful biomarker for evaluating antioxidant levels and oxidative stress.https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4099osteopontinoxidative stressantioxidant statushypothyroidismanemia |
| spellingShingle | Sumesh Prasad Sah Sonu Sah Sudeep Kumar Manisha Arora Dinesh Kumar Raj Kumar Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress International Journal of Integrated Health Sciences osteopontin oxidative stress antioxidant status hypothyroidism anemia |
| title | Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress |
| title_full | Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress |
| title_fullStr | Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress |
| title_full_unstemmed | Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress |
| title_short | Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress |
| title_sort | role of osteopontin in hypothyroid anemic woman and their association with oxidative stress |
| topic | osteopontin oxidative stress antioxidant status hypothyroidism anemia |
| url | https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4099 |
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