Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review.
<h4>Aim</h4>To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients.<h4>Materials and methods</h4>Two independent reviewers screened f...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0145262 |
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| author | Caroline Moura Martins Lobo Santos Ronaldo Lira-Junior Ricardo Guimarães Fischer Ana Paula Pires Santos Branca Heloisa Oliveira |
| author_facet | Caroline Moura Martins Lobo Santos Ronaldo Lira-Junior Ricardo Guimarães Fischer Ana Paula Pires Santos Branca Heloisa Oliveira |
| author_sort | Caroline Moura Martins Lobo Santos |
| collection | DOAJ |
| description | <h4>Aim</h4>To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients.<h4>Materials and methods</h4>Two independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searches yielded 1,878 records; 18 full-text articles were independently read by two reviewers. To evaluate the additional effect of antibiotic usage, pooled weighted mean differences and 95% confidence intervals were calculated using a fixed effects model.<h4>Results</h4>Five studies met the inclusion criteria, four of which were included in meta-analyses. The meta-analyses showed a significant effect favouring SRP plus antibiotic for reductions in mean probing depth (PD) (-0.22 mm [-0.34, -0.11]) and mean percentage of bleeding on probing (BoP) (4% [-7, -1]). There was no significant effect for clinical attachment level gain and plaque index reduction. No study reported on tooth loss and oral health-related quality of life.<h4>Conclusion</h4>Adjunctive systemic antibiotic use in diabetic patients provides a small additional benefit in terms of reductions in mean PD and mean percentage of BoP.<h4>Registration</h4><h4>Prospero</h4>CRD42013006389. |
| format | Article |
| id | doaj-art-eb3e020c286e4cc784b495dbd1e2a96f |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-eb3e020c286e4cc784b495dbd1e2a96f2025-08-20T03:13:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014526210.1371/journal.pone.0145262Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review.Caroline Moura Martins Lobo SantosRonaldo Lira-JuniorRicardo Guimarães FischerAna Paula Pires SantosBranca Heloisa Oliveira<h4>Aim</h4>To evaluate the effects of systemic antibiotics in combination with scaling and root planing (SRP) on periodontal parameters, tooth loss and oral health-related quality of life in diabetes patients.<h4>Materials and methods</h4>Two independent reviewers screened for controlled clinical trials with at least 6-month follow-up in six electronic databases, registers of clinical trials, meeting abstracts and four major dental journals. After duplicates removal, electronic and hand searches yielded 1,878 records; 18 full-text articles were independently read by two reviewers. To evaluate the additional effect of antibiotic usage, pooled weighted mean differences and 95% confidence intervals were calculated using a fixed effects model.<h4>Results</h4>Five studies met the inclusion criteria, four of which were included in meta-analyses. The meta-analyses showed a significant effect favouring SRP plus antibiotic for reductions in mean probing depth (PD) (-0.22 mm [-0.34, -0.11]) and mean percentage of bleeding on probing (BoP) (4% [-7, -1]). There was no significant effect for clinical attachment level gain and plaque index reduction. No study reported on tooth loss and oral health-related quality of life.<h4>Conclusion</h4>Adjunctive systemic antibiotic use in diabetic patients provides a small additional benefit in terms of reductions in mean PD and mean percentage of BoP.<h4>Registration</h4><h4>Prospero</h4>CRD42013006389.https://doi.org/10.1371/journal.pone.0145262 |
| spellingShingle | Caroline Moura Martins Lobo Santos Ronaldo Lira-Junior Ricardo Guimarães Fischer Ana Paula Pires Santos Branca Heloisa Oliveira Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review. PLoS ONE |
| title | Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review. |
| title_full | Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review. |
| title_fullStr | Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review. |
| title_full_unstemmed | Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review. |
| title_short | Systemic Antibiotics in Periodontal Treatment of Diabetic Patients: A Systematic Review. |
| title_sort | systemic antibiotics in periodontal treatment of diabetic patients a systematic review |
| url | https://doi.org/10.1371/journal.pone.0145262 |
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