Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study
ObjectiveTo describe the prevalence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Pudong New Area, Shanghai, and to explore the association between estimated glucose disposal rate (eGDR) and DR, as well as the possibility of eGDR as a predictive marker.MethodsField...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1571488/full |
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| author | Jiaojiao Gao Kang Wu Xiaonan Wang Zhitao Li Xiaolin Liu Jiahui Song Yang Liu Hua Qiu Feng Wei Qian Xu Shaotan Xiao Yi Zhou Xiaonan Ruan |
| author_facet | Jiaojiao Gao Kang Wu Xiaonan Wang Zhitao Li Xiaolin Liu Jiahui Song Yang Liu Hua Qiu Feng Wei Qian Xu Shaotan Xiao Yi Zhou Xiaonan Ruan |
| author_sort | Jiaojiao Gao |
| collection | DOAJ |
| description | ObjectiveTo describe the prevalence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Pudong New Area, Shanghai, and to explore the association between estimated glucose disposal rate (eGDR) and DR, as well as the possibility of eGDR as a predictive marker.MethodsField investigation was conducted among sampled patients with T2DM from May to September 2023. Fundus examination was performed by automatic mydriatless fundus camera to evaluate the prevalence of DR. Restricted cubic spline (RCS) function was employed to evaluate the dose-response relationship between eGDR and DR. Logistic regression analysis was performed to examine their association.ResultsA total of 2,327 patients with T2DM completed the survey, with a median age of 69 years. The prevalence of DR in Pudong New Area was 7.39%, and RCS curve demonstrated a significant negative linear relationship between eGDR and DR. After controlling for confounding factors, the results of the logistics regression showed that the risk of DR decreased by 40.4% for every one standard deviation increase in eGDR. The area under the ROC curve for eGDR predicting DR was 0.777 and 0.781, indicating a high predictive value of eGDR for DR.ConclusionThere is a significant negative linear association between eGDR and the risk of DR, and eGDR is expected to serve as a target for DR prediction and intervention. |
| format | Article |
| id | doaj-art-eb3dc479ec6e48c9bd376d64eebb439d |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-eb3dc479ec6e48c9bd376d64eebb439d2025-08-20T03:26:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15714881571488Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional studyJiaojiao GaoKang WuXiaonan WangZhitao LiXiaolin LiuJiahui SongYang LiuHua QiuFeng WeiQian XuShaotan XiaoYi ZhouXiaonan RuanObjectiveTo describe the prevalence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM) in Pudong New Area, Shanghai, and to explore the association between estimated glucose disposal rate (eGDR) and DR, as well as the possibility of eGDR as a predictive marker.MethodsField investigation was conducted among sampled patients with T2DM from May to September 2023. Fundus examination was performed by automatic mydriatless fundus camera to evaluate the prevalence of DR. Restricted cubic spline (RCS) function was employed to evaluate the dose-response relationship between eGDR and DR. Logistic regression analysis was performed to examine their association.ResultsA total of 2,327 patients with T2DM completed the survey, with a median age of 69 years. The prevalence of DR in Pudong New Area was 7.39%, and RCS curve demonstrated a significant negative linear relationship between eGDR and DR. After controlling for confounding factors, the results of the logistics regression showed that the risk of DR decreased by 40.4% for every one standard deviation increase in eGDR. The area under the ROC curve for eGDR predicting DR was 0.777 and 0.781, indicating a high predictive value of eGDR for DR.ConclusionThere is a significant negative linear association between eGDR and the risk of DR, and eGDR is expected to serve as a target for DR prediction and intervention.https://www.frontiersin.org/articles/10.3389/fendo.2025.1571488/fulldiabetic retinopathyprevalenceinsulin resistanceestimated glucose disposal ratepredictive value |
| spellingShingle | Jiaojiao Gao Kang Wu Xiaonan Wang Zhitao Li Xiaolin Liu Jiahui Song Yang Liu Hua Qiu Feng Wei Qian Xu Shaotan Xiao Yi Zhou Xiaonan Ruan Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study Frontiers in Endocrinology diabetic retinopathy prevalence insulin resistance estimated glucose disposal rate predictive value |
| title | Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study |
| title_full | Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study |
| title_fullStr | Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study |
| title_full_unstemmed | Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study |
| title_short | Study on the prevalence of diabetic retinopathy in Pudong New Area and the predictive value of estimated glucose disposal rate: a cross-sectional study |
| title_sort | study on the prevalence of diabetic retinopathy in pudong new area and the predictive value of estimated glucose disposal rate a cross sectional study |
| topic | diabetic retinopathy prevalence insulin resistance estimated glucose disposal rate predictive value |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1571488/full |
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