LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment

LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment

Abstract Lipid nanoparticle (LNP)-mRNA vaccines have demonstrated protective capability in combating SARS-CoV-2. Their extensive deployment across the global population leads to the broad presence of T-cell immunity against the SARS-CoV-2 spike protein, presenting an opportunity to harness this immu...

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Main Authors: Yonger Xue, Xucheng Hou, Yichen Zhong, Yuebao Zhang, Shi Du, Diana D. Kang, Leiming Wang, Chang Wang, Haoyuan Li, Siyu Wang, Zhengwei Liu, Meng Tian, Kaiyuan Guo, Dinglingge Cao, Binbin Deng, David W. McComb, Eric Purisic, Jinye Dai, Pauline Hamon, Brian D. Brown, Nadejda M. Tsankova, Miriam Merad, Darrell J. Irvine, Ron Weiss, Yizhou Dong
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57149-2
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