Towards precision medicine: design considerations for nanozymes in tumor treatment
Abstract Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class of catalysts, offering advantages such as high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make nanozymes highly...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05845-w |
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| _version_ | 1846164938311073792 |
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| author | Xinqiao Li Jinpeng Hu Qi Zhao Weifeng Yao Zhitao Jing Zhizhong Jin |
| author_facet | Xinqiao Li Jinpeng Hu Qi Zhao Weifeng Yao Zhitao Jing Zhizhong Jin |
| author_sort | Xinqiao Li |
| collection | DOAJ |
| description | Abstract Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class of catalysts, offering advantages such as high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make nanozymes highly suitable for large-scale production. In recent years, the convergence of nanomedicine and nanocatalysis has highlighted the potential of nanozymes in diagnostic and therapeutic applications, particularly in tumor therapy. Despite these advancements, the clinical translation of nanozymes remains hindered by the lack of designs tailored to specific tumor characteristics, limiting their effectiveness in targeted therapy. This review addresses the mechanisms by which nanozymes induce cell death in various tumor types and emphasizes the key design considerations needed to enhance their therapeutic potential. By identifying the challenges and opportunities in the field, this study aims to provide a foundation for future nanozyme development, ultimately contributing to more precise and effective cancer treatments. |
| format | Article |
| id | doaj-art-eb3d2d8100054230ab4f5e30c8c699f8 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-eb3d2d8100054230ab4f5e30c8c699f82024-11-17T12:45:57ZengBMCJournal of Translational Medicine1479-58762024-11-0122112110.1186/s12967-024-05845-wTowards precision medicine: design considerations for nanozymes in tumor treatmentXinqiao Li0Jinpeng Hu1Qi Zhao2Weifeng Yao3Zhitao Jing4Zhizhong Jin5Department of Neurosurgery, The First Hospital of China Medical UniversityDepartment of Neurosurgery, The First Hospital of China Medical UniversityDepartment of Chemistry and the Institute for Sustainability and Energy, Northwestern UniversityShanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, College of Environmental & Chemical Engineering, Shanghai University of Electric PowerDepartment of Neurosurgery, The First Hospital of China Medical UniversityDepartment of Neurosurgery, The First Hospital of China Medical UniversityAbstract Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class of catalysts, offering advantages such as high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make nanozymes highly suitable for large-scale production. In recent years, the convergence of nanomedicine and nanocatalysis has highlighted the potential of nanozymes in diagnostic and therapeutic applications, particularly in tumor therapy. Despite these advancements, the clinical translation of nanozymes remains hindered by the lack of designs tailored to specific tumor characteristics, limiting their effectiveness in targeted therapy. This review addresses the mechanisms by which nanozymes induce cell death in various tumor types and emphasizes the key design considerations needed to enhance their therapeutic potential. By identifying the challenges and opportunities in the field, this study aims to provide a foundation for future nanozyme development, ultimately contributing to more precise and effective cancer treatments.https://doi.org/10.1186/s12967-024-05845-wNanozymeClassificationTumorCancer therapy |
| spellingShingle | Xinqiao Li Jinpeng Hu Qi Zhao Weifeng Yao Zhitao Jing Zhizhong Jin Towards precision medicine: design considerations for nanozymes in tumor treatment Journal of Translational Medicine Nanozyme Classification Tumor Cancer therapy |
| title | Towards precision medicine: design considerations for nanozymes in tumor treatment |
| title_full | Towards precision medicine: design considerations for nanozymes in tumor treatment |
| title_fullStr | Towards precision medicine: design considerations for nanozymes in tumor treatment |
| title_full_unstemmed | Towards precision medicine: design considerations for nanozymes in tumor treatment |
| title_short | Towards precision medicine: design considerations for nanozymes in tumor treatment |
| title_sort | towards precision medicine design considerations for nanozymes in tumor treatment |
| topic | Nanozyme Classification Tumor Cancer therapy |
| url | https://doi.org/10.1186/s12967-024-05845-w |
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