Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate
Drug-induced gingival overgrowth is associated with various systemic diseases, including epilepsy. Among antiepileptic medications, phenytoin is commonly reported to cause this condition. In contrast, sodium valproate (VPA), another widely used antiepileptic drug, rarely induces gingival overgrowth....
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/2/205 |
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| author | Mami Uegami Hiroaki Ito Tadashi Shiohama |
| author_facet | Mami Uegami Hiroaki Ito Tadashi Shiohama |
| author_sort | Mami Uegami |
| collection | DOAJ |
| description | Drug-induced gingival overgrowth is associated with various systemic diseases, including epilepsy. Among antiepileptic medications, phenytoin is commonly reported to cause this condition. In contrast, sodium valproate (VPA), another widely used antiepileptic drug, rarely induces gingival overgrowth. This difference in side effects highlights the variability in drug-induced oral complications among different antiepileptic medications. This case study presents a patient who developed significant gingival overgrowth after using VPA for over 10 years. The study aims to identify VPA as the causative agent and observe changes during long-term administration and after dose reduction. Our findings demonstrate that even long-standing gingival overgrowth can improve rapidly following discontinuation of the causative medication, providing valuable insights for managing similar cases in the future. |
| format | Article |
| id | doaj-art-eb39c49aac4e4a438655b6ebe82f863f |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-eb39c49aac4e4a438655b6ebe82f863f2025-01-24T13:29:06ZengMDPI AGDiagnostics2075-44182025-01-0115220510.3390/diagnostics15020205Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium ValproateMami Uegami0Hiroaki Ito1Tadashi Shiohama2Department of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi 296-8602, Chiba, JapanDepartment of Pediatrics, Kameda Medical Center, 929 Higashi-cho, Kamogawa-shi 296-8602, Chiba, JapanDepartment of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi 260-8670, Chiba, JapanDrug-induced gingival overgrowth is associated with various systemic diseases, including epilepsy. Among antiepileptic medications, phenytoin is commonly reported to cause this condition. In contrast, sodium valproate (VPA), another widely used antiepileptic drug, rarely induces gingival overgrowth. This difference in side effects highlights the variability in drug-induced oral complications among different antiepileptic medications. This case study presents a patient who developed significant gingival overgrowth after using VPA for over 10 years. The study aims to identify VPA as the causative agent and observe changes during long-term administration and after dose reduction. Our findings demonstrate that even long-standing gingival overgrowth can improve rapidly following discontinuation of the causative medication, providing valuable insights for managing similar cases in the future.https://www.mdpi.com/2075-4418/15/2/205gingival overgrowthsodium valproateparoxysmal sympathetic hyperactivity |
| spellingShingle | Mami Uegami Hiroaki Ito Tadashi Shiohama Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate Diagnostics gingival overgrowth sodium valproate paroxysmal sympathetic hyperactivity |
| title | Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate |
| title_full | Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate |
| title_fullStr | Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate |
| title_full_unstemmed | Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate |
| title_short | Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate |
| title_sort | marked gingival overgrowth protruding from the oral cavity due to sodium valproate |
| topic | gingival overgrowth sodium valproate paroxysmal sympathetic hyperactivity |
| url | https://www.mdpi.com/2075-4418/15/2/205 |
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