Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas
Abstract An assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of tumor morphology and MRI characteristics. 74 gross tumor core and T2-FLAIR hyper-intensity BraTS-Toolkit and DeepBraTumIA auto...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85400-9 |
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| author | Valeria Cerina Chiara Benedetta Rui Andrea Di Cristofori Davide Ferlito Giorgio Carrabba Carlo Giussani Gianpaolo Basso Elisabetta De Bernardi |
| author_facet | Valeria Cerina Chiara Benedetta Rui Andrea Di Cristofori Davide Ferlito Giorgio Carrabba Carlo Giussani Gianpaolo Basso Elisabetta De Bernardi |
| author_sort | Valeria Cerina |
| collection | DOAJ |
| description | Abstract An assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of tumor morphology and MRI characteristics. 74 gross tumor core and T2-FLAIR hyper-intensity BraTS-Toolkit and DeepBraTumIA automatic segmentations, and 42 gross tumor core neurosurgeon manual segmentations were accordingly evaluated. Brats-Toolkit and DeepBraTumIA generally provide accurate segmentations, particularly for the most common round-shaped or well-demarked tumors, where: (1) gross tumor segmentation correctly includes necrosis and contrast enhanced tumor in 100% and 97.06% of cases (vs. 73.68% for manual segmentation) and wrongly includes healthy or non-tumor related tissues in 2.94% and 20.59% of cases (vs. 10.53% for manual segmentations); (2) T2-FLAIR hyper-intensity segmentations completely includes edema in 88.24% of cases for both software. MR image quality has little impact on the segmentation performance on these tumors. Conversely, on less common tumors with more complex tissue distribution and infiltrative behavior, manual segmentation works better than BraTS-Toolkit and DeepBraTumIA, and image quality has a larger impact on automatic segmentation performance. BraTS-Toolkit and DeepBraTumIA gross tumor segmentation properly includes necrosis and contrast enhanced areas in 50% and 37.50% of cases (vs. 66.67% for manual segmentation), all corresponding to higher image quality; T2-FLAIR hyper-intensity segmentation wrongly includes necrosis and contrast enhanced areas in 37.50% and 50% of cases. |
| format | Article |
| id | doaj-art-eb353224896e48229d11c1fbb494f203 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-eb353224896e48229d11c1fbb494f2032025-01-19T12:23:04ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-85400-9Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areasValeria Cerina0Chiara Benedetta Rui1Andrea Di Cristofori2Davide Ferlito3Giorgio Carrabba4Carlo Giussani5Gianpaolo Basso6Elisabetta De Bernardi7PhD program in Neuroscience, School of Medicine and Surgery, University of Milano-BicoccaNeurosurgery, Fondazione IRCCS San Gerardo dei TintoriPhD program in Neuroscience, School of Medicine and Surgery, University of Milano-BicoccaNeurosurgery, Fondazione IRCCS San Gerardo dei TintoriNeurosurgery, Fondazione IRCCS San Gerardo dei TintoriNeurosurgery, Fondazione IRCCS San Gerardo dei TintoriCENTRO STUDI DIPARTIMENTALE GBM-BI-TRACE (GlioBlastoMa-BIcocca-TRAnslational-CEnter)CENTRO STUDI DIPARTIMENTALE GBM-BI-TRACE (GlioBlastoMa-BIcocca-TRAnslational-CEnter)Abstract An assessment scheme is proposed to evaluate GBM gross tumor core and T2-FLAIR hyper-intensity segmentations on preoperative multicentric MR images as a function of tumor morphology and MRI characteristics. 74 gross tumor core and T2-FLAIR hyper-intensity BraTS-Toolkit and DeepBraTumIA automatic segmentations, and 42 gross tumor core neurosurgeon manual segmentations were accordingly evaluated. Brats-Toolkit and DeepBraTumIA generally provide accurate segmentations, particularly for the most common round-shaped or well-demarked tumors, where: (1) gross tumor segmentation correctly includes necrosis and contrast enhanced tumor in 100% and 97.06% of cases (vs. 73.68% for manual segmentation) and wrongly includes healthy or non-tumor related tissues in 2.94% and 20.59% of cases (vs. 10.53% for manual segmentations); (2) T2-FLAIR hyper-intensity segmentations completely includes edema in 88.24% of cases for both software. MR image quality has little impact on the segmentation performance on these tumors. Conversely, on less common tumors with more complex tissue distribution and infiltrative behavior, manual segmentation works better than BraTS-Toolkit and DeepBraTumIA, and image quality has a larger impact on automatic segmentation performance. BraTS-Toolkit and DeepBraTumIA gross tumor segmentation properly includes necrosis and contrast enhanced areas in 50% and 37.50% of cases (vs. 66.67% for manual segmentation), all corresponding to higher image quality; T2-FLAIR hyper-intensity segmentation wrongly includes necrosis and contrast enhanced areas in 37.50% and 50% of cases.https://doi.org/10.1038/s41598-025-85400-9GlioblastomaAutomatic segmentationSurgical planningBraTS-ToolkitDeepBraTumIAManual segmentation |
| spellingShingle | Valeria Cerina Chiara Benedetta Rui Andrea Di Cristofori Davide Ferlito Giorgio Carrabba Carlo Giussani Gianpaolo Basso Elisabetta De Bernardi Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas Scientific Reports Glioblastoma Automatic segmentation Surgical planning BraTS-Toolkit DeepBraTumIA Manual segmentation |
| title | Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas |
| title_full | Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas |
| title_fullStr | Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas |
| title_full_unstemmed | Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas |
| title_short | Implication of tumor morphology and MRI characteristics on the accuracy of automated versus human segmentation of GBM areas |
| title_sort | implication of tumor morphology and mri characteristics on the accuracy of automated versus human segmentation of gbm areas |
| topic | Glioblastoma Automatic segmentation Surgical planning BraTS-Toolkit DeepBraTumIA Manual segmentation |
| url | https://doi.org/10.1038/s41598-025-85400-9 |
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