The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations]
Background SARS-CoV-2 first appeared in Wuhan, China, in December 2019. Looking at the prevalence data in the world and in Indonesia, the highest mortality rate due to COVID-19 involves age, gender and comorbidities such as diabetes mellitus. Severity of the condition also refers to coagulation abno...
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F1000 Research Ltd
2024-08-01
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| author | Audrey Fabianisa Mirza Mutiara Indah Sari Ceria Halim |
| author_facet | Audrey Fabianisa Mirza Mutiara Indah Sari Ceria Halim |
| author_sort | Audrey Fabianisa Mirza |
| collection | DOAJ |
| description | Background SARS-CoV-2 first appeared in Wuhan, China, in December 2019. Looking at the prevalence data in the world and in Indonesia, the highest mortality rate due to COVID-19 involves age, gender and comorbidities such as diabetes mellitus. Severity of the condition also refers to coagulation abnormalities, such as abnormal prothrombin time values. Methods This systematic review study and meta-analysis used online literature sourced from PubMed, Science Direct, EBSCO, Cochrane and Google Scholar. The literature used here is literature that has data on age, sex and prothrombin time of COVID-19 patients with diabetes mellitus whose quality is assessed by the NOS (Newcastle-Ottawa Scale) criteria and processing data using Review Manager 5.4. Results Out of 8711 literatures that were traced from various search sources, there were 45 literatures that were included in this study. The results of the analysis on age showed the Standardized Mean Difference (SMD) value of 0.45 and P <0.0001 (95% CI: 0.23–0.68), the gender analysis showed an Odds Ratio (OR) value of 3.28 and P = 0.01 (95% CI: 1.26–8.52) and the prothrombin time analysis showed SMD values of 0.41 and P = 0.07 (95%CI = -0.03–0.85). Conclusion Patients with COVID-19 who have DM have a higher risk compared to those without DM. Among COVID-19 patients with DM admitted to hospitals, they were older compared to those without DM and prothrombin time values similar but slightly higher in COVID-19 patients with DM. |
| format | Article |
| id | doaj-art-eb33f130ddb643eface36848a2f5f070 |
| institution | DOAJ |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-08-01 |
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| spelling | doaj-art-eb33f130ddb643eface36848a2f5f0702025-08-20T02:59:49ZengF1000 Research LtdF1000Research2046-14022024-08-011110.12688/f1000research.107398.6169997The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations]Audrey Fabianisa Mirza0https://orcid.org/0000-0003-2222-8607Mutiara Indah Sari1https://orcid.org/0000-0001-6510-2196Ceria Halim2https://orcid.org/0000-0002-1361-8147Faculty of Medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, IndonesiaDepartment of Biochemistry, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, IndonesiaFaculty of Medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, IndonesiaBackground SARS-CoV-2 first appeared in Wuhan, China, in December 2019. Looking at the prevalence data in the world and in Indonesia, the highest mortality rate due to COVID-19 involves age, gender and comorbidities such as diabetes mellitus. Severity of the condition also refers to coagulation abnormalities, such as abnormal prothrombin time values. Methods This systematic review study and meta-analysis used online literature sourced from PubMed, Science Direct, EBSCO, Cochrane and Google Scholar. The literature used here is literature that has data on age, sex and prothrombin time of COVID-19 patients with diabetes mellitus whose quality is assessed by the NOS (Newcastle-Ottawa Scale) criteria and processing data using Review Manager 5.4. Results Out of 8711 literatures that were traced from various search sources, there were 45 literatures that were included in this study. The results of the analysis on age showed the Standardized Mean Difference (SMD) value of 0.45 and P <0.0001 (95% CI: 0.23–0.68), the gender analysis showed an Odds Ratio (OR) value of 3.28 and P = 0.01 (95% CI: 1.26–8.52) and the prothrombin time analysis showed SMD values of 0.41 and P = 0.07 (95%CI = -0.03–0.85). Conclusion Patients with COVID-19 who have DM have a higher risk compared to those without DM. Among COVID-19 patients with DM admitted to hospitals, they were older compared to those without DM and prothrombin time values similar but slightly higher in COVID-19 patients with DM.https://f1000research.com/articles/11-729/v6age sex prothrombine time COVID-19 diabetes mellitus eng |
| spellingShingle | Audrey Fabianisa Mirza Mutiara Indah Sari Ceria Halim The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations] F1000Research age sex prothrombine time COVID-19 diabetes mellitus eng |
| title | The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations] |
| title_full | The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations] |
| title_fullStr | The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations] |
| title_short | The relationship of age, sex and prothrombin time related to the severity of COVID-19 patients with diabetes mellitus: a systematic review and meta analysis [version 6; peer review: 2 approved, 1 approved with reservations] |
| title_sort | relationship of age sex and prothrombin time related to the severity of covid 19 patients with diabetes mellitus a systematic review and meta analysis version 6 peer review 2 approved 1 approved with reservations |
| topic | age sex prothrombine time COVID-19 diabetes mellitus eng |
| url | https://f1000research.com/articles/11-729/v6 |
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