An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke
Ischemic stroke is a neurological disease characterized by high morbidity and mortality. A key pathological mechanism involves rapid restoration of blood oxygen in the infarcted area, which triggers oxidative stress and inflammatory responses leading to neuronal damage. The complex etiology of the d...
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425006726 |
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| author | Chenjie Xia Changhui Hu Rui Xu Feihong Zhuo Mengfei Yang Yinjia Li Zixuan Shan Cheng Xu Yutong Wang Zhipeng Chen |
| author_facet | Chenjie Xia Changhui Hu Rui Xu Feihong Zhuo Mengfei Yang Yinjia Li Zixuan Shan Cheng Xu Yutong Wang Zhipeng Chen |
| author_sort | Chenjie Xia |
| collection | DOAJ |
| description | Ischemic stroke is a neurological disease characterized by high morbidity and mortality. A key pathological mechanism involves rapid restoration of blood oxygen in the infarcted area, which triggers oxidative stress and inflammatory responses leading to neuronal damage. The complex etiology of the disease poses challenges to single-target pharmacotherapy, necessitating the development of multi-targeted combination drug treatments. Reports showed that water- and lipid-soluble components of Danshen, exert synergistic neuroprotective effects. However, the disparate physicochemical properties of these compounds lead to differential release kinetics, hampering the therapeutic efficacy. Furthermore, the blood-brain barrier (BBB) presents a formidable obstacle to the penetration of water-soluble constituents. Here, we developed a novel biomimetic drug delivery system utilizing hollow polydopamine coated with red blood cell membranes. Water-soluble (W) and lipid-soluble (L) components of Danshen were loaded at distinct membrane regions to facilitate synchronized release profile. Additionally, borneol was used to modify the membrane to enhance the BBB penetration capacity. Mechanism study revealed that W and L possess synergistic effect through inhibiting NF-κB and TNF-α pathways. In summary, this delivery system enables concurrent loading and efficient brain delivery of multiple constituents, thereby promoting neurological recovery and presenting a promising therapeutic strategy for ischemic stroke. |
| format | Article |
| id | doaj-art-eb31c7edb7014c8ebfbc3eb5092e1619 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-eb31c7edb7014c8ebfbc3eb5092e16192025-08-20T03:13:57ZengElsevierMaterials Today Bio2590-00642025-10-013410210210.1016/j.mtbio.2025.102102An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic strokeChenjie Xia0Changhui Hu1Rui Xu2Feihong Zhuo3Mengfei Yang4Yinjia Li5Zixuan Shan6Cheng Xu7Yutong Wang8Zhipeng Chen9Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Department of Pharmacy, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, 214071, ChinaKey Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaKey Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaKey Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaKey Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaKey Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, ChinaSchool of Biopharmacy, China Pharmaceutical University, Nanjing, 211198, ChinaPharmacy Department, Kunshan Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215300, ChinaKey Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Corresponding author.Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Corresponding author.Ischemic stroke is a neurological disease characterized by high morbidity and mortality. A key pathological mechanism involves rapid restoration of blood oxygen in the infarcted area, which triggers oxidative stress and inflammatory responses leading to neuronal damage. The complex etiology of the disease poses challenges to single-target pharmacotherapy, necessitating the development of multi-targeted combination drug treatments. Reports showed that water- and lipid-soluble components of Danshen, exert synergistic neuroprotective effects. However, the disparate physicochemical properties of these compounds lead to differential release kinetics, hampering the therapeutic efficacy. Furthermore, the blood-brain barrier (BBB) presents a formidable obstacle to the penetration of water-soluble constituents. Here, we developed a novel biomimetic drug delivery system utilizing hollow polydopamine coated with red blood cell membranes. Water-soluble (W) and lipid-soluble (L) components of Danshen were loaded at distinct membrane regions to facilitate synchronized release profile. Additionally, borneol was used to modify the membrane to enhance the BBB penetration capacity. Mechanism study revealed that W and L possess synergistic effect through inhibiting NF-κB and TNF-α pathways. In summary, this delivery system enables concurrent loading and efficient brain delivery of multiple constituents, thereby promoting neurological recovery and presenting a promising therapeutic strategy for ischemic stroke.http://www.sciencedirect.com/science/article/pii/S2590006425006726Salvia miltiorrhiza Bge. (Danshen)Multi-componentSynergistic effectBlood-brain barrierCerebral ischemic stroke |
| spellingShingle | Chenjie Xia Changhui Hu Rui Xu Feihong Zhuo Mengfei Yang Yinjia Li Zixuan Shan Cheng Xu Yutong Wang Zhipeng Chen An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke Materials Today Bio Salvia miltiorrhiza Bge. (Danshen) Multi-component Synergistic effect Blood-brain barrier Cerebral ischemic stroke |
| title | An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke |
| title_full | An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke |
| title_fullStr | An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke |
| title_full_unstemmed | An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke |
| title_short | An efficient brain delivery system co-loaded with multiple components of Salvia miltiorrhiza for synergistic treatment of ischemic stroke |
| title_sort | efficient brain delivery system co loaded with multiple components of salvia miltiorrhiza for synergistic treatment of ischemic stroke |
| topic | Salvia miltiorrhiza Bge. (Danshen) Multi-component Synergistic effect Blood-brain barrier Cerebral ischemic stroke |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425006726 |
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