Role of immune inflammation in the pathogenesis of osteoarthrosis and possibilities of correction of immune impairments
A great role in the pathogenesis of osteoarthrosis has been recently assigned to immune impairments, particularly to the involvement of proinflammatory cytokines (interleukin 1 (IL-1), tumor necrosis factor-α (TNF-α)) that activate catabolic processes not only in cartilage tissue, but also in the su...
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| Main Author: | |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2011-12-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/390 |
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| Summary: | A great role in the pathogenesis of osteoarthrosis has been recently assigned to immune impairments, particularly to the involvement of proinflammatory cytokines (interleukin 1 (IL-1), tumor necrosis factor-α (TNF-α)) that activate catabolic processes not only in cartilage tissue, but also in the subchodral bone and other articular structures. Non-steroidal anti-inflammatory drugs, symptomatic slow-acting agents (chondroitin and glucosamine sulfate), as well as diacerein that blocks IL-1 directly and TNF-α indirectly, reduce the activity of cytokines to some extent. |
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| ISSN: | 1996-7012 2310-158X |