Secondary HLH Case Report Highlighting Clinical Challenges
A 19-year-old patient with relapsed acute myeloid leukemia (AML) developed severe and prolonged cytopenia and unexplained jaundice and fever after salvage chemotherapy. His workup revealed hemophagocytosis on the bone marrow biopsy. He was treated for HLH (hemophagocytic lymphohistiocytosis) seconda...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2018/1913938 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849690591839911936 |
|---|---|
| author | Riad El Fakih Said Y. Mohamed Randa Alnounou Ghada Elgohary |
| author_facet | Riad El Fakih Said Y. Mohamed Randa Alnounou Ghada Elgohary |
| author_sort | Riad El Fakih |
| collection | DOAJ |
| description | A 19-year-old patient with relapsed acute myeloid leukemia (AML) developed severe and prolonged cytopenia and unexplained jaundice and fever after salvage chemotherapy. His workup revealed hemophagocytosis on the bone marrow biopsy. He was treated for HLH (hemophagocytic lymphohistiocytosis) secondary to AML and chemotherapy. The patient died on day 56 after starting his salvage chemotherapy. Unexpectedly, after his death, the microbiology laboratory reported positive mycobacterial growth from a bronchoalveolar lavage (BAL) sample taken during the workup of his fever. This case illustrates the difficulties in the diagnostic workup of HLH to identify triggers in a timely manner so that a targeted and specific therapy can be administered quickly, given the rapid and deadly evolution of the HLH process. |
| format | Article |
| id | doaj-art-eb2af842b3c046c2bcce454fe05edca2 |
| institution | DOAJ |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-eb2af842b3c046c2bcce454fe05edca22025-08-20T03:21:16ZengWileyCase Reports in Hematology2090-65602090-65792018-01-01201810.1155/2018/19139381913938Secondary HLH Case Report Highlighting Clinical ChallengesRiad El Fakih0Said Y. Mohamed1Randa Alnounou2Ghada Elgohary3King Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi ArabiaKing Faisal Specialist Hospital and Research Center, P.O. Box 3354, Riyadh 11211, Saudi ArabiaA 19-year-old patient with relapsed acute myeloid leukemia (AML) developed severe and prolonged cytopenia and unexplained jaundice and fever after salvage chemotherapy. His workup revealed hemophagocytosis on the bone marrow biopsy. He was treated for HLH (hemophagocytic lymphohistiocytosis) secondary to AML and chemotherapy. The patient died on day 56 after starting his salvage chemotherapy. Unexpectedly, after his death, the microbiology laboratory reported positive mycobacterial growth from a bronchoalveolar lavage (BAL) sample taken during the workup of his fever. This case illustrates the difficulties in the diagnostic workup of HLH to identify triggers in a timely manner so that a targeted and specific therapy can be administered quickly, given the rapid and deadly evolution of the HLH process.http://dx.doi.org/10.1155/2018/1913938 |
| spellingShingle | Riad El Fakih Said Y. Mohamed Randa Alnounou Ghada Elgohary Secondary HLH Case Report Highlighting Clinical Challenges Case Reports in Hematology |
| title | Secondary HLH Case Report Highlighting Clinical Challenges |
| title_full | Secondary HLH Case Report Highlighting Clinical Challenges |
| title_fullStr | Secondary HLH Case Report Highlighting Clinical Challenges |
| title_full_unstemmed | Secondary HLH Case Report Highlighting Clinical Challenges |
| title_short | Secondary HLH Case Report Highlighting Clinical Challenges |
| title_sort | secondary hlh case report highlighting clinical challenges |
| url | http://dx.doi.org/10.1155/2018/1913938 |
| work_keys_str_mv | AT riadelfakih secondaryhlhcasereporthighlightingclinicalchallenges AT saidymohamed secondaryhlhcasereporthighlightingclinicalchallenges AT randaalnounou secondaryhlhcasereporthighlightingclinicalchallenges AT ghadaelgohary secondaryhlhcasereporthighlightingclinicalchallenges |