Synthesis of Spiro Heterocyclic Compounds
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea afforded new spiropyrazolines (IV & V) a...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/604549 |
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| _version_ | 1850164122137657344 |
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| author | Mohamed N. Ibrahim Mohamed F. El-Messmary Mohamed G. A. Elarfi |
| author_facet | Mohamed N. Ibrahim Mohamed F. El-Messmary Mohamed G. A. Elarfi |
| author_sort | Mohamed N. Ibrahim |
| collection | DOAJ |
| description | Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea afforded new spiropyrazolines (IV & V) and spiropyrimidinethione (VI) respectively. The structures of the final products were established by physical and spectral means. |
| format | Article |
| id | doaj-art-eb2aa569c76c4e8fa0d7d03cb952223c |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-eb2aa569c76c4e8fa0d7d03cb952223c2025-08-20T02:22:03ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-0171555810.1155/2010/604549Synthesis of Spiro Heterocyclic CompoundsMohamed N. Ibrahim0Mohamed F. El-Messmary1Mohamed G. A. Elarfi2Chemistry Department, Faculty of Science, Garyounis University, Benghazi, LibyaChemistry Department, Faculty of Science, Garyounis University, Benghazi, LibyaChemistry Department, Faculty of Science, Garyounis University, Benghazi, LibyaReaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III). Condensation of (III) with hydrazine hydrate, phenylhydrazine and phenylthiourea afforded new spiropyrazolines (IV & V) and spiropyrimidinethione (VI) respectively. The structures of the final products were established by physical and spectral means.http://dx.doi.org/10.1155/2010/604549 |
| spellingShingle | Mohamed N. Ibrahim Mohamed F. El-Messmary Mohamed G. A. Elarfi Synthesis of Spiro Heterocyclic Compounds E-Journal of Chemistry |
| title | Synthesis of Spiro Heterocyclic Compounds |
| title_full | Synthesis of Spiro Heterocyclic Compounds |
| title_fullStr | Synthesis of Spiro Heterocyclic Compounds |
| title_full_unstemmed | Synthesis of Spiro Heterocyclic Compounds |
| title_short | Synthesis of Spiro Heterocyclic Compounds |
| title_sort | synthesis of spiro heterocyclic compounds |
| url | http://dx.doi.org/10.1155/2010/604549 |
| work_keys_str_mv | AT mohamednibrahim synthesisofspiroheterocycliccompounds AT mohamedfelmessmary synthesisofspiroheterocycliccompounds AT mohamedgaelarfi synthesisofspiroheterocycliccompounds |