Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications.
<h4>Objectives</h4>This case-control study aims to clarify the impact of single nucleotide polymorphisms (SNPs) within the P2X7 gene on susceptibility to type 2 diabetes mellitus (T2DM) and to evaluate their association with diabetic complications.<h4>Methods</h4>This study i...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0318134 |
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| author | Guoni Huang Jing Cheng Wenfeng Liu Tong Yang Tao Ye Qian Zhang Qi Chen Yuzhong Xu |
| author_facet | Guoni Huang Jing Cheng Wenfeng Liu Tong Yang Tao Ye Qian Zhang Qi Chen Yuzhong Xu |
| author_sort | Guoni Huang |
| collection | DOAJ |
| description | <h4>Objectives</h4>This case-control study aims to clarify the impact of single nucleotide polymorphisms (SNPs) within the P2X7 gene on susceptibility to type 2 diabetes mellitus (T2DM) and to evaluate their association with diabetic complications.<h4>Methods</h4>This study is comprised with 200 T2DM cases and 200 healthy controls. Seven candidate SNP loci were screened, and TaqMan-MGB real-time PCR technology was used to determine the polymorphic variants of P2X7. Different genotype and allele frequencies were compared by Pearson's χ2 tests and logistic regression analysis.<h4>Results</h4>Three P2X7 SNPs were found to be associated with T2DM risk. Specifically, rs7958311 GA (OR = 1.323, p = 0.002), rs7958311 AA (OR = 1.508, p = 0.038), rs208294 CC (OR = 1.854, p = 0.042) showed a higher susceptibility to T2DM, whilst rs11065464 CA (OR = 0.614, p = 0.022) was associated with a reduced risk. Logistic regression analysis indicated that rs7958311 was linked to an increased risk for nephropathy (OR = 1.833, p = 0.022), but with a decreased risk for peripheral artery disease (OR = 0.550, p = 0.042). Additionally, rs208294 was identified as a risk factor for peripheral neuropathy (OR = 2.101, p = 0.016).<h4>Conclusions</h4>We found that P2X7 polymorphisms are significantly associated with the risk of T2DM and its complications, suggesting that targeting P2X7 may offer a novel therapeutic strategy for the prevention and personal treatment of T2DM. |
| format | Article |
| id | doaj-art-eb29f0aed5d7402dbe60beed3f85962a |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-eb29f0aed5d7402dbe60beed3f85962a2025-02-05T05:32:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031813410.1371/journal.pone.0318134Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications.Guoni HuangJing ChengWenfeng LiuTong YangTao YeQian ZhangQi ChenYuzhong Xu<h4>Objectives</h4>This case-control study aims to clarify the impact of single nucleotide polymorphisms (SNPs) within the P2X7 gene on susceptibility to type 2 diabetes mellitus (T2DM) and to evaluate their association with diabetic complications.<h4>Methods</h4>This study is comprised with 200 T2DM cases and 200 healthy controls. Seven candidate SNP loci were screened, and TaqMan-MGB real-time PCR technology was used to determine the polymorphic variants of P2X7. Different genotype and allele frequencies were compared by Pearson's χ2 tests and logistic regression analysis.<h4>Results</h4>Three P2X7 SNPs were found to be associated with T2DM risk. Specifically, rs7958311 GA (OR = 1.323, p = 0.002), rs7958311 AA (OR = 1.508, p = 0.038), rs208294 CC (OR = 1.854, p = 0.042) showed a higher susceptibility to T2DM, whilst rs11065464 CA (OR = 0.614, p = 0.022) was associated with a reduced risk. Logistic regression analysis indicated that rs7958311 was linked to an increased risk for nephropathy (OR = 1.833, p = 0.022), but with a decreased risk for peripheral artery disease (OR = 0.550, p = 0.042). Additionally, rs208294 was identified as a risk factor for peripheral neuropathy (OR = 2.101, p = 0.016).<h4>Conclusions</h4>We found that P2X7 polymorphisms are significantly associated with the risk of T2DM and its complications, suggesting that targeting P2X7 may offer a novel therapeutic strategy for the prevention and personal treatment of T2DM.https://doi.org/10.1371/journal.pone.0318134 |
| spellingShingle | Guoni Huang Jing Cheng Wenfeng Liu Tong Yang Tao Ye Qian Zhang Qi Chen Yuzhong Xu Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. PLoS ONE |
| title | Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. |
| title_full | Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. |
| title_fullStr | Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. |
| title_full_unstemmed | Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. |
| title_short | Association of P2X7 polymorphisms on Type 2 diabetes mellitus susceptibility and diabetic complications. |
| title_sort | association of p2x7 polymorphisms on type 2 diabetes mellitus susceptibility and diabetic complications |
| url | https://doi.org/10.1371/journal.pone.0318134 |
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