Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases
Objectives Aortic dissection (AD) is a life-threatening condition that requires intensive care and management. This paper explores the role of fluid management in the clinical care of AD patients, which has been unclear despite the substantial existing research that has been conducted on the treatme...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-02-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/2/e083933.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864522179346432 |
|---|---|
| author | Tao Chen Peng Qiu Yixuan Li Xinwu Lu Zhaoyu Wu Zhijue Xu Hongji Pu Jiahao Lei Zhuojing Zhang Xinrui Yang Ruihua Wang |
| author_facet | Tao Chen Peng Qiu Yixuan Li Xinwu Lu Zhaoyu Wu Zhijue Xu Hongji Pu Jiahao Lei Zhuojing Zhang Xinrui Yang Ruihua Wang |
| author_sort | Tao Chen |
| collection | DOAJ |
| description | Objectives Aortic dissection (AD) is a life-threatening condition that requires intensive care and management. This paper explores the role of fluid management in the clinical care of AD patients, which has been unclear despite the substantial existing research that has been conducted on the treatment of AD.Design A retrospective case-control study using data for AD patients from public databases.Setting Two public intensive care unit (ICU) databases with hospital courses from the USA, Medical Information Mart for Intensive Care (MIMIC)-IV critical care dataset and the eICU Collaborative Research Database, with data from 2008 to 2019.Participants A total of 751 adult AD patients with detailed fluid management records from two databases were included.Interventions The mean 24-hour intake and output were calculated by dividing the total amount of intake and output by the number of days in the ICU, respectively. The mean 24-hour fluid balance was generated by subtracting the output from the intake.Outcome measures The relationship between the mean 24-hour fluid management and all-cause in-hospital death was assessed through univariate and multivariable regression analyses.Results A positive correlation was found between mean 24-hour fluid intake and in-hospital mortality among AD patients (OR 1.029, 95% CI (1.018, 1.041), p<0.001), whereas a negative correlation was revealed between mean 24-hour fluid output and in-hospital mortality (OR 0.941, 95% CI (0.914, 0.968), p<0.001). A similar result was found for mean 24-hour fluid balance (OR 1.030, 95% CI (1.019, 1.042), p<0.001), and the cut-off was selected to be 5.12 dL (AUC=0.778, OR 3.066, 95% CI (1.634, 5.753), p<0.001).Conclusions This study stresses the importance of fluid balance in the clinical care of AD patients and provides new insights for optimising fluid management and monitoring strategies beyond the conventional focus on blood pressure and heart rate management. |
| format | Article |
| id | doaj-art-eb23401f1acd49628485d8158af28a93 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-eb23401f1acd49628485d8158af28a932025-02-09T04:55:09ZengBMJ Publishing GroupBMJ Open2044-60552025-02-0115210.1136/bmjopen-2024-083933Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databasesTao Chen0Peng Qiu1Yixuan Li2Xinwu Lu3Zhaoyu Wu4Zhijue Xu5Hongji Pu6Jiahao Lei7Zhuojing Zhang8Xinrui Yang9Ruihua Wang10Big Data Research Lab, University of Waterloo, Waterloo, Ontario, CanadaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaBig Data Research Lab, University of Waterloo, Waterloo, Ontario, CanadaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaDepartment of Economics, University of Waterloo, Waterloo, Ontario, CanadaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaDepartment of Vascular Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People`s Hospital, Shanghai, ChinaObjectives Aortic dissection (AD) is a life-threatening condition that requires intensive care and management. This paper explores the role of fluid management in the clinical care of AD patients, which has been unclear despite the substantial existing research that has been conducted on the treatment of AD.Design A retrospective case-control study using data for AD patients from public databases.Setting Two public intensive care unit (ICU) databases with hospital courses from the USA, Medical Information Mart for Intensive Care (MIMIC)-IV critical care dataset and the eICU Collaborative Research Database, with data from 2008 to 2019.Participants A total of 751 adult AD patients with detailed fluid management records from two databases were included.Interventions The mean 24-hour intake and output were calculated by dividing the total amount of intake and output by the number of days in the ICU, respectively. The mean 24-hour fluid balance was generated by subtracting the output from the intake.Outcome measures The relationship between the mean 24-hour fluid management and all-cause in-hospital death was assessed through univariate and multivariable regression analyses.Results A positive correlation was found between mean 24-hour fluid intake and in-hospital mortality among AD patients (OR 1.029, 95% CI (1.018, 1.041), p<0.001), whereas a negative correlation was revealed between mean 24-hour fluid output and in-hospital mortality (OR 0.941, 95% CI (0.914, 0.968), p<0.001). A similar result was found for mean 24-hour fluid balance (OR 1.030, 95% CI (1.019, 1.042), p<0.001), and the cut-off was selected to be 5.12 dL (AUC=0.778, OR 3.066, 95% CI (1.634, 5.753), p<0.001).Conclusions This study stresses the importance of fluid balance in the clinical care of AD patients and provides new insights for optimising fluid management and monitoring strategies beyond the conventional focus on blood pressure and heart rate management.https://bmjopen.bmj.com/content/15/2/e083933.full |
| spellingShingle | Tao Chen Peng Qiu Yixuan Li Xinwu Lu Zhaoyu Wu Zhijue Xu Hongji Pu Jiahao Lei Zhuojing Zhang Xinrui Yang Ruihua Wang Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases BMJ Open |
| title | Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases |
| title_full | Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases |
| title_fullStr | Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases |
| title_full_unstemmed | Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases |
| title_short | Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases |
| title_sort | fluid balance and clinical outcomes in patients with aortic dissection a retrospective case control study based on icu databases |
| url | https://bmjopen.bmj.com/content/15/2/e083933.full |
| work_keys_str_mv | AT taochen fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT pengqiu fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT yixuanli fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT xinwulu fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT zhaoyuwu fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT zhijuexu fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT hongjipu fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT jiahaolei fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT zhuojingzhang fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT xinruiyang fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases AT ruihuawang fluidbalanceandclinicaloutcomesinpatientswithaorticdissectionaretrospectivecasecontrolstudybasedonicudatabases |